Polarized macrophages modulate cardiac structure and contractility under hypoxia in novel immuno-heart on a chip

Polarized macrophages modulate cardiac structure and contractility under hypoxia in novel immuno-heart on a chip

Cardiac adaptation to hypoxic injury is regulated by dynamic interactions between cardiomyocytes and macrophages, yet the impacts of immune phenotypes on cardiac structure and contractility remain poorly understood. To address this, we developed the immuno-heart on a chip, a novel in vitro platform...

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Bibliographic Details
Main Authors: Andrew A. Schmidt, Li-Mor David, Nida T. Qayyum, Khanh Tran, Cassandra Van, Ali H. S. H. A. Hetta, Ronit L. Shrestha, Ashley O. Varatip, Sergei Butenko, Daniela Enriquez-Ochoa, Christy Nguyen, Marcus M. Seldin, Wendy F. Liu, Anna Grosberg
Format: Article
Language:English
Published: AIP Publishing LLC 2025-06-01
Series:APL Bioengineering
Online Access:http://dx.doi.org/10.1063/5.0253888
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