Autophagy and autophagic cell death in sepsis: friend or foe?

Autophagy and autophagic cell death in sepsis: friend or foe?

Abstract In sepsis, inflammation, and nutrient deficiencies endanger cellular homeostasis and survival. Autophagy is primarily a mechanism of cellular survival under fasting conditions. However, autophagy-dependent cell death, known as autophagic cell death, is proinflammatory and can exacerbate sep...

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Bibliographic Details
Main Authors: Toshiaki Iba, Julie Helms, Cheryl L. Maier, Ricard Ferrer, Jerrold H. Levy
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Journal of Intensive Care
Subjects:
Autophagy
Sepsis
Mitochondria
Apoptosis
Necrosis
Mitophagy
Online Access:https://doi.org/10.1186/s40560-024-00754-y
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