The Impact of Bioactive Lipids on Cardiovascular Development
Lysophospholipids comprise a group of bioactive molecules with multiple biological functions. The cardinal members of this signalling molecule group are sphingosylphosphorylcholine (SPC), lysophosphatidic acid...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.4061/2011/916180 |
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| author | Alexander Kleger Stefan Liebau Qiong Lin Götz von Wichert Thomas Seufferlein |
| author_facet | Alexander Kleger Stefan Liebau Qiong Lin Götz von Wichert Thomas Seufferlein |
| author_sort | Alexander Kleger |
| collection | DOAJ |
| description | Lysophospholipids comprise a group of bioactive molecules with multiple
biological functions. The cardinal members of this signalling molecule
group are sphingosylphosphorylcholine (SPC), lysophosphatidic acid
(LPA), and sphingosine 1-phosphate (S1P) which are, at least in part,
homologous to each other. Bioactive lipids usually act via G-protein
coupled receptors (GPCRs), but can also function as direct
intracellular messengers. Recently, it became evident that bioactive
lipids play a role during cellular differentiation development. SPC
induces mesodermal differentiation of mouse ES cells
and differentiation of promyelocytic leukemia cells,
by a mechanism being critically dependent on
MEK-ERK signalling. LPA stimulates the clonal expansion of neurospheres
from neural stem/progenitor cells and induces c-fos via activation of
mitogen- and stress-activated protein kinase 1 (MSK1) in ES cells. S1P acts on hematopoietic progenitor cells as a
chemotactic factor and has also been found to be critical for
cardiac and skeletal muscle regeneration. Furthermore, S1P promotes
cardiogenesis and similarly activates Erk signalling in mouse ES
cells. Interestingly, S1P may also act to maintain human stem cell
pluripotency. Both LPA and S1P positively regulate the proliferative
capacity of murine ES cells. In this paper we will focus on the
differential and developmental impact of lysophospholipids on
cardiovascular development. |
| format | Article |
| id | doaj-art-934665c2b7eb4607890ae4e257a2f5ad |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-934665c2b7eb4607890ae4e257a2f5ad2025-02-03T01:00:57ZengWileyStem Cells International1687-966X1687-96782011-01-01201110.4061/2011/916180916180The Impact of Bioactive Lipids on Cardiovascular DevelopmentAlexander Kleger0Stefan Liebau1Qiong Lin2Götz von Wichert3Thomas Seufferlein4Department of Internal Medicine I, University of Ulm, 89081 Ulm, GermanyInstitute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, GermanyInstitute for Biomedical Engineering, Department of Cell Biology, RWTH Aachen University Medical School, 52074 Aachen, GermanyDepartment of Internal Medicine I, Martin Luther University Halle-Wittenberg (Saale), 06120 Halle, GermanyDepartment of Internal Medicine I, Division of Medicine, Martin Luther University Halle-Wittenberg (Saale), 06120 Halle, GermanyLysophospholipids comprise a group of bioactive molecules with multiple biological functions. The cardinal members of this signalling molecule group are sphingosylphosphorylcholine (SPC), lysophosphatidic acid (LPA), and sphingosine 1-phosphate (S1P) which are, at least in part, homologous to each other. Bioactive lipids usually act via G-protein coupled receptors (GPCRs), but can also function as direct intracellular messengers. Recently, it became evident that bioactive lipids play a role during cellular differentiation development. SPC induces mesodermal differentiation of mouse ES cells and differentiation of promyelocytic leukemia cells, by a mechanism being critically dependent on MEK-ERK signalling. LPA stimulates the clonal expansion of neurospheres from neural stem/progenitor cells and induces c-fos via activation of mitogen- and stress-activated protein kinase 1 (MSK1) in ES cells. S1P acts on hematopoietic progenitor cells as a chemotactic factor and has also been found to be critical for cardiac and skeletal muscle regeneration. Furthermore, S1P promotes cardiogenesis and similarly activates Erk signalling in mouse ES cells. Interestingly, S1P may also act to maintain human stem cell pluripotency. Both LPA and S1P positively regulate the proliferative capacity of murine ES cells. In this paper we will focus on the differential and developmental impact of lysophospholipids on cardiovascular development.http://dx.doi.org/10.4061/2011/916180 |
| spellingShingle | Alexander Kleger Stefan Liebau Qiong Lin Götz von Wichert Thomas Seufferlein The Impact of Bioactive Lipids on Cardiovascular Development Stem Cells International |
| title | The Impact of Bioactive Lipids on Cardiovascular
Development |
| title_full | The Impact of Bioactive Lipids on Cardiovascular
Development |
| title_fullStr | The Impact of Bioactive Lipids on Cardiovascular
Development |
| title_full_unstemmed | The Impact of Bioactive Lipids on Cardiovascular
Development |
| title_short | The Impact of Bioactive Lipids on Cardiovascular
Development |
| title_sort | impact of bioactive lipids on cardiovascular development |
| url | http://dx.doi.org/10.4061/2011/916180 |
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