Hypothalamic AMPK as a Regulator of Energy Homeostasis
Activated in energy depletion conditions, AMP-activated protein kinase (AMPK) acts as a cellular energy sensor and regulator in both central nervous system and peripheral organs. Hypothalamic AMPK restores energy balance by promoting feeding behavior to increase energy intake, increasing glucose pro...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/2754078 |
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| _version_ | 1832548963430957056 |
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| author | My Khanh Q. Huynh Ann W. Kinyua Dong Joo Yang Ki Woo Kim |
| author_facet | My Khanh Q. Huynh Ann W. Kinyua Dong Joo Yang Ki Woo Kim |
| author_sort | My Khanh Q. Huynh |
| collection | DOAJ |
| description | Activated in energy depletion conditions, AMP-activated protein kinase (AMPK) acts as a cellular energy sensor and regulator in both central nervous system and peripheral organs. Hypothalamic AMPK restores energy balance by promoting feeding behavior to increase energy intake, increasing glucose production, and reducing thermogenesis to decrease energy output. Besides energy state, many hormones have been shown to act in concert with AMPK to mediate their anorexigenic and orexigenic central effects as well as thermogenic influences. Here we explore the factors that affect hypothalamic AMPK activity and give the underlying mechanisms for the role of central AMPK in energy homeostasis together with the physiological effects of hypothalamic AMPK on energy balance restoration. |
| format | Article |
| id | doaj-art-934555c745b64bf4908b1ca770bdea5c |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-934555c745b64bf4908b1ca770bdea5c2025-02-03T06:12:39ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/27540782754078Hypothalamic AMPK as a Regulator of Energy HomeostasisMy Khanh Q. Huynh0Ann W. Kinyua1Dong Joo Yang2Ki Woo Kim3Departments of Pharmacology and Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of KoreaDepartments of Pharmacology and Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of KoreaDepartments of Pharmacology and Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of KoreaDepartments of Pharmacology and Global Medical Science, Wonju College of Medicine, Yonsei University, Wonju 26426, Republic of KoreaActivated in energy depletion conditions, AMP-activated protein kinase (AMPK) acts as a cellular energy sensor and regulator in both central nervous system and peripheral organs. Hypothalamic AMPK restores energy balance by promoting feeding behavior to increase energy intake, increasing glucose production, and reducing thermogenesis to decrease energy output. Besides energy state, many hormones have been shown to act in concert with AMPK to mediate their anorexigenic and orexigenic central effects as well as thermogenic influences. Here we explore the factors that affect hypothalamic AMPK activity and give the underlying mechanisms for the role of central AMPK in energy homeostasis together with the physiological effects of hypothalamic AMPK on energy balance restoration.http://dx.doi.org/10.1155/2016/2754078 |
| spellingShingle | My Khanh Q. Huynh Ann W. Kinyua Dong Joo Yang Ki Woo Kim Hypothalamic AMPK as a Regulator of Energy Homeostasis Neural Plasticity |
| title | Hypothalamic AMPK as a Regulator of Energy Homeostasis |
| title_full | Hypothalamic AMPK as a Regulator of Energy Homeostasis |
| title_fullStr | Hypothalamic AMPK as a Regulator of Energy Homeostasis |
| title_full_unstemmed | Hypothalamic AMPK as a Regulator of Energy Homeostasis |
| title_short | Hypothalamic AMPK as a Regulator of Energy Homeostasis |
| title_sort | hypothalamic ampk as a regulator of energy homeostasis |
| url | http://dx.doi.org/10.1155/2016/2754078 |
| work_keys_str_mv | AT mykhanhqhuynh hypothalamicampkasaregulatorofenergyhomeostasis AT annwkinyua hypothalamicampkasaregulatorofenergyhomeostasis AT dongjooyang hypothalamicampkasaregulatorofenergyhomeostasis AT kiwookim hypothalamicampkasaregulatorofenergyhomeostasis |