Nasal Nitric Oxide as an Objective Evaluation Tool for Treatment Response in Chronic Rhinitis
Background and Objectives Inconsistencies in nasal nitric oxide (nNO) values, due to anatomical variations and comorbidities, challenge the accurate assessment of upper airway inflammation severity. We hypothesized that changes in nNO levels following treatment for chronic rhinitis would be consiste...
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Korean Rhinologic Society
2025-03-01
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| Series: | Journal of Rhinology |
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| Online Access: | http://j-rhinology.org/upload/pdf/jr-2025-00009.pdf |
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| author | Sangeun Lee Su Mi Seong Hyeop Oh Jihun Yoon Bo Hae Kim Joo Hyun Park Yun-Sung Lim Chang Gun Cho Seok-Won Park Jin Youp Kim |
| author_facet | Sangeun Lee Su Mi Seong Hyeop Oh Jihun Yoon Bo Hae Kim Joo Hyun Park Yun-Sung Lim Chang Gun Cho Seok-Won Park Jin Youp Kim |
| author_sort | Sangeun Lee |
| collection | DOAJ |
| description | Background and Objectives Inconsistencies in nasal nitric oxide (nNO) values, due to anatomical variations and comorbidities, challenge the accurate assessment of upper airway inflammation severity. We hypothesized that changes in nNO levels following treatment for chronic rhinitis would be consistent and provide relative value. This study aimed to evaluate the correlation between changes in nNO levels and symptomatic improvements following treatment for chronic rhinitis. Methods This prospective observational study included 46 participants diagnosed with chronic rhinitis between December 2021 and November 2023. nNO measurements, evaluations of four nasal and two ocular symptoms, and quality of life questionnaires were conducted at baseline and after one month of treatment. Baseline laboratory tests included serum total immunoglobulin E levels, blood eosinophil percentages, and skin prick tests. Results The Total Nasal Symptom Score (TNSS), TNSS with ocular symptoms (TNSS eye), and Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) scores significantly decreased following treatment (all p<0.001). nNO levels also decreased significantly after treatment (p=0.036). Moreover, changes in nNO were significantly correlated with changes in TNSS, TNSS eye, and RQLQ scores (p=0.047, r=0.294; p=0.021, r=0.340; and p=0.004, r=0.419, respectively). Conclusion In patients with chronic rhinitis, changes in TNSS, TNSS eye, and RQLQ scores were correlated with changes in nNO levels after treatment. nNO may serve as a potential objective evaluation tool for chronic rhinitis, particularly in patients who have difficulty reporting symptoms. |
| format | Article |
| id | doaj-art-9330ebedd10a4d2ebb1e8a8dd2e050e6 |
| institution | OA Journals |
| issn | 1229-1498 2384-4361 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Korean Rhinologic Society |
| record_format | Article |
| series | Journal of Rhinology |
| spelling | doaj-art-9330ebedd10a4d2ebb1e8a8dd2e050e62025-08-20T02:32:14ZengKorean Rhinologic SocietyJournal of Rhinology1229-14982384-43612025-03-01321404710.18787/jr.2025.00009834Nasal Nitric Oxide as an Objective Evaluation Tool for Treatment Response in Chronic RhinitisSangeun Lee0Su Mi Seong1Hyeop Oh2Jihun Yoon3Bo Hae Kim4Joo Hyun Park5Yun-Sung Lim6Chang Gun Cho7Seok-Won Park8Jin Youp Kim9 Department of Otorhinolaryngology-Head and Neck Surgery, Ilsan Hospital, Dongguk University, Goyang, Republic of Korea Department of Otorhinolaryngology-Head and Neck Surgery, Ilsan Hospital, Dongguk University, Goyang, Republic of Korea Department of Otorhinolaryngology-Head and Neck Surgery, Ilsan Hospital, Dongguk University, Goyang, Republic of Korea Department of Otorhinolaryngology-Head and Neck Surgery, Ilsan Hospital, Dongguk University, Goyang, Republic of Korea Department of Otorhinolaryngology-Head and Neck Surgery, Ilsan Hospital, Dongguk University, Goyang, Republic of Korea Department of Otorhinolaryngology-Head and Neck Surgery, Ilsan Hospital, Dongguk University, Goyang, Republic of Korea Department of Otorhinolaryngology-Head and Neck Surgery, Ilsan Hospital, Dongguk University, Goyang, Republic of Korea Department of Otorhinolaryngology-Head and Neck Surgery, Ilsan Hospital, Dongguk University, Goyang, Republic of Korea Department of Otorhinolaryngology-Head and Neck Surgery, Ilsan Hospital, Dongguk University, Goyang, Republic of Korea Department of Otorhinolaryngology-Head and Neck Surgery, Ilsan Hospital, Dongguk University, Goyang, Republic of KoreaBackground and Objectives Inconsistencies in nasal nitric oxide (nNO) values, due to anatomical variations and comorbidities, challenge the accurate assessment of upper airway inflammation severity. We hypothesized that changes in nNO levels following treatment for chronic rhinitis would be consistent and provide relative value. This study aimed to evaluate the correlation between changes in nNO levels and symptomatic improvements following treatment for chronic rhinitis. Methods This prospective observational study included 46 participants diagnosed with chronic rhinitis between December 2021 and November 2023. nNO measurements, evaluations of four nasal and two ocular symptoms, and quality of life questionnaires were conducted at baseline and after one month of treatment. Baseline laboratory tests included serum total immunoglobulin E levels, blood eosinophil percentages, and skin prick tests. Results The Total Nasal Symptom Score (TNSS), TNSS with ocular symptoms (TNSS eye), and Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) scores significantly decreased following treatment (all p<0.001). nNO levels also decreased significantly after treatment (p=0.036). Moreover, changes in nNO were significantly correlated with changes in TNSS, TNSS eye, and RQLQ scores (p=0.047, r=0.294; p=0.021, r=0.340; and p=0.004, r=0.419, respectively). Conclusion In patients with chronic rhinitis, changes in TNSS, TNSS eye, and RQLQ scores were correlated with changes in nNO levels after treatment. nNO may serve as a potential objective evaluation tool for chronic rhinitis, particularly in patients who have difficulty reporting symptoms.http://j-rhinology.org/upload/pdf/jr-2025-00009.pdfrhinitisbiomarkersnitric oxide |
| spellingShingle | Sangeun Lee Su Mi Seong Hyeop Oh Jihun Yoon Bo Hae Kim Joo Hyun Park Yun-Sung Lim Chang Gun Cho Seok-Won Park Jin Youp Kim Nasal Nitric Oxide as an Objective Evaluation Tool for Treatment Response in Chronic Rhinitis Journal of Rhinology rhinitis biomarkers nitric oxide |
| title | Nasal Nitric Oxide as an Objective Evaluation Tool for Treatment Response in Chronic Rhinitis |
| title_full | Nasal Nitric Oxide as an Objective Evaluation Tool for Treatment Response in Chronic Rhinitis |
| title_fullStr | Nasal Nitric Oxide as an Objective Evaluation Tool for Treatment Response in Chronic Rhinitis |
| title_full_unstemmed | Nasal Nitric Oxide as an Objective Evaluation Tool for Treatment Response in Chronic Rhinitis |
| title_short | Nasal Nitric Oxide as an Objective Evaluation Tool for Treatment Response in Chronic Rhinitis |
| title_sort | nasal nitric oxide as an objective evaluation tool for treatment response in chronic rhinitis |
| topic | rhinitis biomarkers nitric oxide |
| url | http://j-rhinology.org/upload/pdf/jr-2025-00009.pdf |
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