Insights into Neonatal Oral Feeding through the Salivary Transcriptome
Background. The development of safe and effective oral feeding skills in the newborn is complex and may be associated with significant morbidities. Our understanding of neonatal oral feeding maturation at the molecular level is limited, providing an opportunity to utilize emerging molecular techniqu...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2012/195153 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832564068127342592 |
|---|---|
| author | Jill L. Maron |
| author_facet | Jill L. Maron |
| author_sort | Jill L. Maron |
| collection | DOAJ |
| description | Background. The development of safe and effective oral feeding skills in the newborn is complex and may be associated with significant morbidities. Our understanding of neonatal oral feeding maturation at the molecular level is limited, providing an opportunity to utilize emerging molecular techniques to accurately assess neonatal oral feeding skills. Objective. To identify key regulatory genes in neonatal saliva involved in successful oral feeding. Methods. Previously, our laboratory identified 9,286 genes in saliva that statistically significantly altered their gene expression as premature newborns gained advanced oral feeding skills. In this report, genes previously identified underwent an updated and targeted pathway analysis with Ingenuity Pathway Analysis (IPA) to identify potential candidate genes involved in successful oral feeding. Genes were considered if they were in the five most significantly up- and down-regulated physiological pathways and were associated with the keywords “feeding”, “digestion” and “development”. Results. There were 2,186 genes that met criteria. Pathways associated with feeding behavior, cranial nerve development, and the development of the nervous, skeletal, and muscular systems were highlighted. Discussion. These data provide important insights into the biological processes involved in oral feeding in the newborn at a molecular level and identify novel pathways associated with successful oral feeding. |
| format | Article |
| id | doaj-art-932defd176084b58b3af1f37e2c381f4 |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-932defd176084b58b3af1f37e2c381f42025-02-03T01:11:55ZengWileyInternational Journal of Pediatrics1687-97401687-97592012-01-01201210.1155/2012/195153195153Insights into Neonatal Oral Feeding through the Salivary TranscriptomeJill L. Maron0Division of Newborn Medicine, Mother Infant Research Institute at Tufts Medical Center, Floating Hospital for Children at Tufts Medical Center, 800 Washington Street, P.O. Box 394, Boston, MA 02111, USABackground. The development of safe and effective oral feeding skills in the newborn is complex and may be associated with significant morbidities. Our understanding of neonatal oral feeding maturation at the molecular level is limited, providing an opportunity to utilize emerging molecular techniques to accurately assess neonatal oral feeding skills. Objective. To identify key regulatory genes in neonatal saliva involved in successful oral feeding. Methods. Previously, our laboratory identified 9,286 genes in saliva that statistically significantly altered their gene expression as premature newborns gained advanced oral feeding skills. In this report, genes previously identified underwent an updated and targeted pathway analysis with Ingenuity Pathway Analysis (IPA) to identify potential candidate genes involved in successful oral feeding. Genes were considered if they were in the five most significantly up- and down-regulated physiological pathways and were associated with the keywords “feeding”, “digestion” and “development”. Results. There were 2,186 genes that met criteria. Pathways associated with feeding behavior, cranial nerve development, and the development of the nervous, skeletal, and muscular systems were highlighted. Discussion. These data provide important insights into the biological processes involved in oral feeding in the newborn at a molecular level and identify novel pathways associated with successful oral feeding.http://dx.doi.org/10.1155/2012/195153 |
| spellingShingle | Jill L. Maron Insights into Neonatal Oral Feeding through the Salivary Transcriptome International Journal of Pediatrics |
| title | Insights into Neonatal Oral Feeding through the Salivary Transcriptome |
| title_full | Insights into Neonatal Oral Feeding through the Salivary Transcriptome |
| title_fullStr | Insights into Neonatal Oral Feeding through the Salivary Transcriptome |
| title_full_unstemmed | Insights into Neonatal Oral Feeding through the Salivary Transcriptome |
| title_short | Insights into Neonatal Oral Feeding through the Salivary Transcriptome |
| title_sort | insights into neonatal oral feeding through the salivary transcriptome |
| url | http://dx.doi.org/10.1155/2012/195153 |
| work_keys_str_mv | AT jilllmaron insightsintoneonataloralfeedingthroughthesalivarytranscriptome |