Characteristics of Suppressor Macrophages Induced by Mycobacterial and Protozoal Infections in relation to Alternatively Activated M2 Macrophages
In the advanced stages of mycobacterial infections, host immune systems tend to change from a Th1-type to Th2-type immune response, resulting in the abrogation of Th1 cell- and macrophage-mediated antimicrobial host protective immunity. Notably, this type of immune conversion is occasionally associa...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/635451 |
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| author | Haruaki Tomioka Yutaka Tatano Win Win Maw Chiaki Sano Yuichi Kanehiro Toshiaki Shimizu |
| author_facet | Haruaki Tomioka Yutaka Tatano Win Win Maw Chiaki Sano Yuichi Kanehiro Toshiaki Shimizu |
| author_sort | Haruaki Tomioka |
| collection | DOAJ |
| description | In the advanced stages of mycobacterial infections, host immune systems tend to change from a Th1-type to Th2-type immune response, resulting in the abrogation of Th1 cell- and macrophage-mediated antimicrobial host protective immunity. Notably, this type of immune conversion is occasionally associated with the generation of certain types of suppressor macrophage populations. During the course of Mycobacterium tuberculosis (MTB) and Mycobacterium avium-intracellulare complex (MAC) infections, the generation of macrophages which possess strong suppressor activity against host T- and B-cell functions is frequently encountered. This paper describes the immunological properties of M1- and M2-type macrophages generated in tumor-bearing animals and those generated in hosts with certain microbial infections. In addition, this paper highlights the immunological and molecular biological characteristics of suppressor macrophages generated in hosts with mycobacterial infections, especially MAC infection. |
| format | Article |
| id | doaj-art-932debe54b0c417985d628da9a8e0b50 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-932debe54b0c417985d628da9a8e0b502025-02-03T05:46:09ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/635451635451Characteristics of Suppressor Macrophages Induced by Mycobacterial and Protozoal Infections in relation to Alternatively Activated M2 MacrophagesHaruaki Tomioka0Yutaka Tatano1Win Win Maw2Chiaki Sano3Yuichi Kanehiro4Toshiaki Shimizu5Department of Microbiology and Immunology, Shimane University School of Medicine, Izumo, Shimane 693-8501, JapanDepartment of Microbiology and Immunology, Shimane University School of Medicine, Izumo, Shimane 693-8501, JapanDepartment of Microbiology and Immunology, Shimane University School of Medicine, Izumo, Shimane 693-8501, JapanDepartment of Microbiology and Immunology, Shimane University School of Medicine, Izumo, Shimane 693-8501, JapanDepartment of Microbiology and Immunology, Shimane University School of Medicine, Izumo, Shimane 693-8501, JapanDepartment of Nutritional Sciences, Faculty of Home Economics, Yasuda Women’s University, Hiroshima 731-0153, JapanIn the advanced stages of mycobacterial infections, host immune systems tend to change from a Th1-type to Th2-type immune response, resulting in the abrogation of Th1 cell- and macrophage-mediated antimicrobial host protective immunity. Notably, this type of immune conversion is occasionally associated with the generation of certain types of suppressor macrophage populations. During the course of Mycobacterium tuberculosis (MTB) and Mycobacterium avium-intracellulare complex (MAC) infections, the generation of macrophages which possess strong suppressor activity against host T- and B-cell functions is frequently encountered. This paper describes the immunological properties of M1- and M2-type macrophages generated in tumor-bearing animals and those generated in hosts with certain microbial infections. In addition, this paper highlights the immunological and molecular biological characteristics of suppressor macrophages generated in hosts with mycobacterial infections, especially MAC infection.http://dx.doi.org/10.1155/2012/635451 |
| spellingShingle | Haruaki Tomioka Yutaka Tatano Win Win Maw Chiaki Sano Yuichi Kanehiro Toshiaki Shimizu Characteristics of Suppressor Macrophages Induced by Mycobacterial and Protozoal Infections in relation to Alternatively Activated M2 Macrophages Clinical and Developmental Immunology |
| title | Characteristics of Suppressor Macrophages Induced by Mycobacterial and Protozoal Infections in relation to Alternatively Activated M2 Macrophages |
| title_full | Characteristics of Suppressor Macrophages Induced by Mycobacterial and Protozoal Infections in relation to Alternatively Activated M2 Macrophages |
| title_fullStr | Characteristics of Suppressor Macrophages Induced by Mycobacterial and Protozoal Infections in relation to Alternatively Activated M2 Macrophages |
| title_full_unstemmed | Characteristics of Suppressor Macrophages Induced by Mycobacterial and Protozoal Infections in relation to Alternatively Activated M2 Macrophages |
| title_short | Characteristics of Suppressor Macrophages Induced by Mycobacterial and Protozoal Infections in relation to Alternatively Activated M2 Macrophages |
| title_sort | characteristics of suppressor macrophages induced by mycobacterial and protozoal infections in relation to alternatively activated m2 macrophages |
| url | http://dx.doi.org/10.1155/2012/635451 |
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