Exploring the Therapeutic Potential of the DOT1L Inhibitor EPZ004777 Using Bioinformatics and Molecular Docking Approaches in Acute Myeloid Leukemia

Exploring the Therapeutic Potential of the DOT1L Inhibitor EPZ004777 Using Bioinformatics and Molecular Docking Approaches in Acute Myeloid Leukemia

Background: Acute myeloid leukemia (AML) is a malignancy characterized by the clonal expansion of hematopoietic stem and progenitor cells, often associated with mutations such as NPM1. DOT1L inhibitors have shown potential as new therapeutic opportunities for NPM1-mutant AML. The aim of this study w...

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Bibliographic Details
Main Authors: Mehmet Kivrak, Ihsan Nalkiran, Hatice Sevim Nalkiran
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Current Issues in Molecular Biology
Subjects:
acute myeloid leukemia
transcriptomics
bioinformatics
molecular docking
Online Access:https://www.mdpi.com/1467-3045/47/3/173
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