Lentiviral-Mediated shRNA Silencing of PDE4D Gene Inhibits Platelet-Derived Growth Factor-Induced Proliferation and Migration of Rat Aortic Smooth Muscle Cells

Lentiviral-Mediated shRNA Silencing of PDE4D Gene Inhibits Platelet-Derived Growth Factor-Induced Proliferation and Migration of Rat Aortic Smooth Muscle Cells

Phosphodiesterase 4D (PDE4D) is a member of the large superfamily of phosphodiesterases. PDE4D polymorphisms have been found to associate with ischemic stroke. Proliferation and migration of vascular smooth muscle cells (VSMCs) play a critical role in the pathogenesis of atherosclerosis. In this stu...

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Bibliographic Details
Main Authors:	Lin Liu, Xiaowei Xu, Jiejie Li, Xia Li, Wenli Sheng
Format:	Article
Language:	English
Published:	Wiley 2011-01-01
Series:	Stroke Research and Treatment
Online Access:	http://dx.doi.org/10.4061/2011/534257
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