A new NCL-targeting aptamer-drug conjugate as a promising therapy against esophageal cancer

Abstract Esophageal cancer (EC) is one of the most common highly malignant tumors of the digestive system, with a poor prognosis under current treatment regimens. Nucleolin (NCL) is overexpressed in many tumors, and drugs specifically targeting NCL may offer a promising strategy for treating esophag...

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Bibliographic Details
Main Authors: Xue Zheng, Ying Wang, Huaiyu Duan, Junqi Hou, Shiming He
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Journal of Nanobiotechnology
Subjects:
Online Access:https://doi.org/10.1186/s12951-025-03127-1
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