Prevalence of Pulmonary Embolism in COVID-19 Positive Critically Ill Children
OBJECTIVES:. To investigate the prevalence of pulmonary embolism (PE) in children admitted to critical care diagnosed with COVID-19 infection. DESIGN:. Retrospective database study. SETTING:. Data reported to the Virtual Pediatric Systems, 2018–2021. PATIENTS:. Patients 28 days to younger than 18 ye...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2025-01-01
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| Series: | Critical Care Explorations |
| Online Access: | http://journals.lww.com/10.1097/CCE.0000000000001206 |
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| author | Yudy Fonseca, MD Alise Davies, PA Stephanie Jarrin, MD Liliana Simon, MD Cortney Foster, DO Sun Kai Adnan Bhutta, MD |
| author_facet | Yudy Fonseca, MD Alise Davies, PA Stephanie Jarrin, MD Liliana Simon, MD Cortney Foster, DO Sun Kai Adnan Bhutta, MD |
| author_sort | Yudy Fonseca, MD |
| collection | DOAJ |
| description | OBJECTIVES:. To investigate the prevalence of pulmonary embolism (PE) in children admitted to critical care diagnosed with COVID-19 infection.
DESIGN:. Retrospective database study.
SETTING:. Data reported to the Virtual Pediatric Systems, 2018–2021.
PATIENTS:. Patients 28 days to younger than 18 years old, admitted to a PICU with either PE or COVID-19 diagnoses.
INTERVENTIONS:. None.
MEASUREMENTS AND MAIN RESULTS:. Among the PE-positive subgroups, from January 2020 to December 2021, 78 patients (14%) had an acute COVID-19 infection. The prevalence of PE pre-pandemic period (2018–2019) was 0.19% and for pandemic period (2020–2021) was 0.26% (p < 0.001). During the pandemic period, the prevalence of PE for COVID-negative patients was 0.21% and for COVID-positive patients was 1.01% (p < 0.001). The result shows that the chance to develop PE for COVID-positive patients is 4.8 times that for COVID-negative patients during the pandemic. In the subgroup of the PE-positive patients, 55.1% were Black or African American in the COVID-positive group and 19% in the COVID-negative group (p < 0.001). A multivariable logistic regression showed that race was an independent risk factor for COVID in PE-positive patients.
CONCLUSIONS:. Our study demonstrates a significant increase in the prevalence of PE among pediatric patients admitted to PICUs during the COVID-19 pandemic compared with pre-pandemic. Our study indicates that COVID-positive patients are 4.8 times more likely to develop PE than COVID-negative patients. Additionally, the study highlights substantial racial disparities in the prevalence of PE, with Black or African American patients being disproportionately affected. |
| format | Article |
| id | doaj-art-9311f87f5f7c4e7fb2c6a061752f6027 |
| institution | Kabale University |
| issn | 2639-8028 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Critical Care Explorations |
| spelling | doaj-art-9311f87f5f7c4e7fb2c6a061752f60272025-01-24T09:19:27ZengWolters KluwerCritical Care Explorations2639-80282025-01-0171e120610.1097/CCE.0000000000001206202501000-00008Prevalence of Pulmonary Embolism in COVID-19 Positive Critically Ill ChildrenYudy Fonseca, MD0Alise Davies, PA1Stephanie Jarrin, MD2Liliana Simon, MD3Cortney Foster, DO4Sun Kai5Adnan Bhutta, MD61 Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Maryland, Baltimore, MD.1 Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Maryland, Baltimore, MD.1 Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Maryland, Baltimore, MD.1 Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Maryland, Baltimore, MD.1 Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Maryland, Baltimore, MD.2 Division of Biostatistics and Bioinformatics, Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD.3 Division of Pediatric Critical Care Medicine, Department of Pediatrics, Indiana University School of Medicine/Riley Children’s Health, Indianapolis, IN.OBJECTIVES:. To investigate the prevalence of pulmonary embolism (PE) in children admitted to critical care diagnosed with COVID-19 infection. DESIGN:. Retrospective database study. SETTING:. Data reported to the Virtual Pediatric Systems, 2018–2021. PATIENTS:. Patients 28 days to younger than 18 years old, admitted to a PICU with either PE or COVID-19 diagnoses. INTERVENTIONS:. None. MEASUREMENTS AND MAIN RESULTS:. Among the PE-positive subgroups, from January 2020 to December 2021, 78 patients (14%) had an acute COVID-19 infection. The prevalence of PE pre-pandemic period (2018–2019) was 0.19% and for pandemic period (2020–2021) was 0.26% (p < 0.001). During the pandemic period, the prevalence of PE for COVID-negative patients was 0.21% and for COVID-positive patients was 1.01% (p < 0.001). The result shows that the chance to develop PE for COVID-positive patients is 4.8 times that for COVID-negative patients during the pandemic. In the subgroup of the PE-positive patients, 55.1% were Black or African American in the COVID-positive group and 19% in the COVID-negative group (p < 0.001). A multivariable logistic regression showed that race was an independent risk factor for COVID in PE-positive patients. CONCLUSIONS:. Our study demonstrates a significant increase in the prevalence of PE among pediatric patients admitted to PICUs during the COVID-19 pandemic compared with pre-pandemic. Our study indicates that COVID-positive patients are 4.8 times more likely to develop PE than COVID-negative patients. Additionally, the study highlights substantial racial disparities in the prevalence of PE, with Black or African American patients being disproportionately affected.http://journals.lww.com/10.1097/CCE.0000000000001206 |
| spellingShingle | Yudy Fonseca, MD Alise Davies, PA Stephanie Jarrin, MD Liliana Simon, MD Cortney Foster, DO Sun Kai Adnan Bhutta, MD Prevalence of Pulmonary Embolism in COVID-19 Positive Critically Ill Children Critical Care Explorations |
| title | Prevalence of Pulmonary Embolism in COVID-19 Positive Critically Ill Children |
| title_full | Prevalence of Pulmonary Embolism in COVID-19 Positive Critically Ill Children |
| title_fullStr | Prevalence of Pulmonary Embolism in COVID-19 Positive Critically Ill Children |
| title_full_unstemmed | Prevalence of Pulmonary Embolism in COVID-19 Positive Critically Ill Children |
| title_short | Prevalence of Pulmonary Embolism in COVID-19 Positive Critically Ill Children |
| title_sort | prevalence of pulmonary embolism in covid 19 positive critically ill children |
| url | http://journals.lww.com/10.1097/CCE.0000000000001206 |
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