Reducing oxidative stress and hepatoprotective effect of water extracts from Pu-erh tea on rats with high-fat diet
Reducing oxidative stress and hepatoprotective effect of Pu-erh tea water extracts on rats fed with high-fat diet were researched for explaining health care of Pu-erh tea. Fifty SD rats were divided into five groups. The body weight was measured once a day. The malondialdehyde (MDA) and glucose (Glu...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2016-12-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453016300246 |
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| author | Jingjing Su Xueqing Wang Wenjun Song Xiaoli Bai Changwen Li |
| author_facet | Jingjing Su Xueqing Wang Wenjun Song Xiaoli Bai Changwen Li |
| author_sort | Jingjing Su |
| collection | DOAJ |
| description | Reducing oxidative stress and hepatoprotective effect of Pu-erh tea water extracts on rats fed with high-fat diet were researched for explaining health care of Pu-erh tea. Fifty SD rats were divided into five groups. The body weight was measured once a day. The malondialdehyde (MDA) and glucose (Glu) levels and the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), nitric oxide synthase (NOS), and pyruvate kinase (PK) in serum were determined. Furthermore, the hepatic glycogen level (HGL) and the activities of hepatic total superoxide dismutase (T-SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) were also measured after continuous administration for 12 weeks. The result demonstrated that Pu-erh extract caused the decreases in body weight, fat index, MDA and NOS levels, and the increases in hepatic T-SOD, CAT and GSH-Px activities, indicating that the extract may be due to inhibiting the increases of body weight and fat index, reducing oxidant stress state and inhibiting lipid peroxidation, thus decreasing the activities of ALT and AST, and protecting the liver in rat. Meanwhile, the extracts could increase the production of hepatic glycogen and the activity of PK, and reduce glucose level, protecting the liver from the diseases associated with type II diabetes. |
| format | Article |
| id | doaj-art-930b15f77bb348dbb1776685553f7370 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2016-12-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-930b15f77bb348dbb1776685553f73702025-02-03T05:38:58ZengTsinghua University PressFood Science and Human Wellness2213-45302016-12-015419920610.1016/j.fshw.2016.09.002Reducing oxidative stress and hepatoprotective effect of water extracts from Pu-erh tea on rats with high-fat dietJingjing Su0Xueqing Wang1Wenjun Song2Xiaoli Bai3Changwen Li4Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, ChinaTianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, ChinaTianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin 300134, ChinaYunnan Tasly Deepure Biological Tea Group Company Limited, Pu Erh, Yunnan 665100, ChinaYunnan Tasly Deepure Biological Tea Group Company Limited, Pu Erh, Yunnan 665100, ChinaReducing oxidative stress and hepatoprotective effect of Pu-erh tea water extracts on rats fed with high-fat diet were researched for explaining health care of Pu-erh tea. Fifty SD rats were divided into five groups. The body weight was measured once a day. The malondialdehyde (MDA) and glucose (Glu) levels and the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), nitric oxide synthase (NOS), and pyruvate kinase (PK) in serum were determined. Furthermore, the hepatic glycogen level (HGL) and the activities of hepatic total superoxide dismutase (T-SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) were also measured after continuous administration for 12 weeks. The result demonstrated that Pu-erh extract caused the decreases in body weight, fat index, MDA and NOS levels, and the increases in hepatic T-SOD, CAT and GSH-Px activities, indicating that the extract may be due to inhibiting the increases of body weight and fat index, reducing oxidant stress state and inhibiting lipid peroxidation, thus decreasing the activities of ALT and AST, and protecting the liver in rat. Meanwhile, the extracts could increase the production of hepatic glycogen and the activity of PK, and reduce glucose level, protecting the liver from the diseases associated with type II diabetes.http://www.sciencedirect.com/science/article/pii/S2213453016300246Pu-erh tea extractsOxidative stressHepatoprotective effect |
| spellingShingle | Jingjing Su Xueqing Wang Wenjun Song Xiaoli Bai Changwen Li Reducing oxidative stress and hepatoprotective effect of water extracts from Pu-erh tea on rats with high-fat diet Food Science and Human Wellness Pu-erh tea extracts Oxidative stress Hepatoprotective effect |
| title | Reducing oxidative stress and hepatoprotective effect of water extracts from Pu-erh tea on rats with high-fat diet |
| title_full | Reducing oxidative stress and hepatoprotective effect of water extracts from Pu-erh tea on rats with high-fat diet |
| title_fullStr | Reducing oxidative stress and hepatoprotective effect of water extracts from Pu-erh tea on rats with high-fat diet |
| title_full_unstemmed | Reducing oxidative stress and hepatoprotective effect of water extracts from Pu-erh tea on rats with high-fat diet |
| title_short | Reducing oxidative stress and hepatoprotective effect of water extracts from Pu-erh tea on rats with high-fat diet |
| title_sort | reducing oxidative stress and hepatoprotective effect of water extracts from pu erh tea on rats with high fat diet |
| topic | Pu-erh tea extracts Oxidative stress Hepatoprotective effect |
| url | http://www.sciencedirect.com/science/article/pii/S2213453016300246 |
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