Total Adiponectin Is Inversely Associated with Platelet Activation and CHA2DS2-VASc Score in Anticoagulated Patients with Atrial Fibrillation
Background. Adiponectin (APN) possesses anti-inflammatory and antiatherogenic effects. Atrial fibrillation (AF) is burdened by enhanced systemic inflammation and platelet activation, as documented by increased blood levels of soluble CD40L (sCD40L). The interplay between APN and platelet activation...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/908901 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832548558023163904 |
|---|---|
| author | Roberto Carnevale Daniele Pastori Mariangela Peruzzi Elena De Falco Isotta Chimenti Giuseppe Biondi-Zoccai Ernesto Greco Antonino G. M. Marullo Cristina Nocella Francesco Violi Pasquale Pignatelli Camilla Calvieri Giacomo Frati |
| author_facet | Roberto Carnevale Daniele Pastori Mariangela Peruzzi Elena De Falco Isotta Chimenti Giuseppe Biondi-Zoccai Ernesto Greco Antonino G. M. Marullo Cristina Nocella Francesco Violi Pasquale Pignatelli Camilla Calvieri Giacomo Frati |
| author_sort | Roberto Carnevale |
| collection | DOAJ |
| description | Background. Adiponectin (APN) possesses anti-inflammatory and antiatherogenic effects. Atrial fibrillation (AF) is burdened by enhanced systemic inflammation and platelet activation, as documented by increased blood levels of soluble CD40L (sCD40L). The interplay between APN and platelet activation in AF is still undefined. Materials and Methods. Circulating levels of APN and sCD40L were measured in 257 anticoagulated nonvalvular AF patients. Exclusion criteria were as follows: prosthetic heart valves, cardiac revascularization in the previous year, severe cognitive impairment, chronic infectious or autoimmune diseases, and active cancer. Results. Mean age was 72.9 (±8.7) years and 41.6% were female. Serum APN and plasmatic sCD40L were inversely correlated (R −0.626, P<0.001). A progressive increase of sCD40L across tertiles of CHA2DS2-VASc score was observed (rS 0.473, P<0.001), whilst APN was inversely correlated (rS −0.463, P<0.001). A multivariable linear regression analysis showed that CHA2DS2-VASc score (B −0.227, P<0.001) and sCD40L (B −0.524, P<0.001) correlated to APN. Conclusions. AF patients at high risk of stroke disclose low and high levels of APN and sCD40L, respectively, suggesting a role for APN if it favors platelet activation in vivo in this clinical setting. Enhancing APN levels may be a future goal to reduce the risk of vascular outcomes in AF patients. |
| format | Article |
| id | doaj-art-930726988adb4fe99b7339e9edf930d1 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-930726988adb4fe99b7339e9edf930d12025-02-03T06:13:50ZengWileyMediators of Inflammation0962-93511466-18612014-01-01201410.1155/2014/908901908901Total Adiponectin Is Inversely Associated with Platelet Activation and CHA2DS2-VASc Score in Anticoagulated Patients with Atrial FibrillationRoberto Carnevale0Daniele Pastori1Mariangela Peruzzi2Elena De Falco3Isotta Chimenti4Giuseppe Biondi-Zoccai5Ernesto Greco6Antonino G. M. Marullo7Cristina Nocella8Francesco Violi9Pasquale Pignatelli10Camilla Calvieri11Giacomo Frati12Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Internal Medicine and Medical Specialties, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, ItalyDepartment of Cardiovascular, Respiratory, Nephrological, Anesthesiological, and Geriatric Sciences, Policlinico Umberto, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, ItalyDepartment of Internal Medicine and Medical Specialties, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Internal Medicine and Medical Specialties, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Internal Medicine and Medical Specialties, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Internal Medicine and Medical Specialties, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, 04100 Latina, ItalyBackground. Adiponectin (APN) possesses anti-inflammatory and antiatherogenic effects. Atrial fibrillation (AF) is burdened by enhanced systemic inflammation and platelet activation, as documented by increased blood levels of soluble CD40L (sCD40L). The interplay between APN and platelet activation in AF is still undefined. Materials and Methods. Circulating levels of APN and sCD40L were measured in 257 anticoagulated nonvalvular AF patients. Exclusion criteria were as follows: prosthetic heart valves, cardiac revascularization in the previous year, severe cognitive impairment, chronic infectious or autoimmune diseases, and active cancer. Results. Mean age was 72.9 (±8.7) years and 41.6% were female. Serum APN and plasmatic sCD40L were inversely correlated (R −0.626, P<0.001). A progressive increase of sCD40L across tertiles of CHA2DS2-VASc score was observed (rS 0.473, P<0.001), whilst APN was inversely correlated (rS −0.463, P<0.001). A multivariable linear regression analysis showed that CHA2DS2-VASc score (B −0.227, P<0.001) and sCD40L (B −0.524, P<0.001) correlated to APN. Conclusions. AF patients at high risk of stroke disclose low and high levels of APN and sCD40L, respectively, suggesting a role for APN if it favors platelet activation in vivo in this clinical setting. Enhancing APN levels may be a future goal to reduce the risk of vascular outcomes in AF patients.http://dx.doi.org/10.1155/2014/908901 |
| spellingShingle | Roberto Carnevale Daniele Pastori Mariangela Peruzzi Elena De Falco Isotta Chimenti Giuseppe Biondi-Zoccai Ernesto Greco Antonino G. M. Marullo Cristina Nocella Francesco Violi Pasquale Pignatelli Camilla Calvieri Giacomo Frati Total Adiponectin Is Inversely Associated with Platelet Activation and CHA2DS2-VASc Score in Anticoagulated Patients with Atrial Fibrillation Mediators of Inflammation |
| title | Total Adiponectin Is Inversely Associated with Platelet Activation and CHA2DS2-VASc Score in Anticoagulated Patients with Atrial Fibrillation |
| title_full | Total Adiponectin Is Inversely Associated with Platelet Activation and CHA2DS2-VASc Score in Anticoagulated Patients with Atrial Fibrillation |
| title_fullStr | Total Adiponectin Is Inversely Associated with Platelet Activation and CHA2DS2-VASc Score in Anticoagulated Patients with Atrial Fibrillation |
| title_full_unstemmed | Total Adiponectin Is Inversely Associated with Platelet Activation and CHA2DS2-VASc Score in Anticoagulated Patients with Atrial Fibrillation |
| title_short | Total Adiponectin Is Inversely Associated with Platelet Activation and CHA2DS2-VASc Score in Anticoagulated Patients with Atrial Fibrillation |
| title_sort | total adiponectin is inversely associated with platelet activation and cha2ds2 vasc score in anticoagulated patients with atrial fibrillation |
| url | http://dx.doi.org/10.1155/2014/908901 |
| work_keys_str_mv | AT robertocarnevale totaladiponectinisinverselyassociatedwithplateletactivationandcha2ds2vascscoreinanticoagulatedpatientswithatrialfibrillation AT danielepastori totaladiponectinisinverselyassociatedwithplateletactivationandcha2ds2vascscoreinanticoagulatedpatientswithatrialfibrillation AT mariangelaperuzzi totaladiponectinisinverselyassociatedwithplateletactivationandcha2ds2vascscoreinanticoagulatedpatientswithatrialfibrillation AT elenadefalco totaladiponectinisinverselyassociatedwithplateletactivationandcha2ds2vascscoreinanticoagulatedpatientswithatrialfibrillation AT isottachimenti totaladiponectinisinverselyassociatedwithplateletactivationandcha2ds2vascscoreinanticoagulatedpatientswithatrialfibrillation AT giuseppebiondizoccai totaladiponectinisinverselyassociatedwithplateletactivationandcha2ds2vascscoreinanticoagulatedpatientswithatrialfibrillation AT ernestogreco totaladiponectinisinverselyassociatedwithplateletactivationandcha2ds2vascscoreinanticoagulatedpatientswithatrialfibrillation AT antoninogmmarullo totaladiponectinisinverselyassociatedwithplateletactivationandcha2ds2vascscoreinanticoagulatedpatientswithatrialfibrillation AT cristinanocella totaladiponectinisinverselyassociatedwithplateletactivationandcha2ds2vascscoreinanticoagulatedpatientswithatrialfibrillation AT francescovioli totaladiponectinisinverselyassociatedwithplateletactivationandcha2ds2vascscoreinanticoagulatedpatientswithatrialfibrillation AT pasqualepignatelli totaladiponectinisinverselyassociatedwithplateletactivationandcha2ds2vascscoreinanticoagulatedpatientswithatrialfibrillation AT camillacalvieri totaladiponectinisinverselyassociatedwithplateletactivationandcha2ds2vascscoreinanticoagulatedpatientswithatrialfibrillation AT giacomofrati totaladiponectinisinverselyassociatedwithplateletactivationandcha2ds2vascscoreinanticoagulatedpatientswithatrialfibrillation |