Immunomodulation with M2 macrophage–derived extracellular vesicles for enhanced titanium implant osseointegration under diabetic conditions

Immunomodulation with M2 macrophage–derived extracellular vesicles for enhanced titanium implant osseointegration under diabetic conditions

M2 macrophage–derived extracellular vesicles (M2-EVs) demonstrate the capacity to reduce pro-inflammatory M1 macrophage formation, thereby restoring the M1–M2 macrophage balance and promoting immunoregulation. However, the efficacy of M2-EVs in regulating macrophage polarization and subsequently enh...

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Bibliographic Details
Main Authors:	Yuzhao Cheng, Xin Dong, Jing Shi, Guangsheng Wu, Pei Tao, Nan Ren, Yimin Zhao, Fenglan Li, Zhongshan Wang
Format:	Article
Language:	English
Published:	Elsevier 2025-02-01
Series:	Materials Today Bio
Subjects:	Ti implants Diabetes mellitus Osseointegration Macrophage NLRP3 inflammasome
Online Access:	http://www.sciencedirect.com/science/article/pii/S2590006424004460
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