Parallel in vitro ion channel and in vivo zebrafish assaying of elapid snake venoms following chromatographic separation of toxin components

Parallel in vitro ion channel and in vivo zebrafish assaying of elapid snake venoms following chromatographic separation of toxin components

Snake venoms are complex bioactive mixtures designed to paralyse, kill, or digest prey. These venoms are of pharmacological interest due to their ability to modulate molecular targets such as ion channels and receptors with high specificity and potency. Traditional studies often focus on in vitro mo...

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Bibliographic Details
Main Authors: Arif Arrahman, Haifeng Xu, Muzaffar A. Khan, Tijmen S. Bos, Julien Slagboom, Guus C. van der Velden, Ulrike Nehrdich, Nicholas R. Casewell, Michael K. Richardson, Christian Tudorache, Fernanda C. Cardoso, Jeroen Kool
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:SLAS Discovery
Subjects:
Elapid snake venom
zebrafish in vivo assay
ion channel in vitro assays
mass spectrometry
nanofractionation
toxicity assay
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555225000322
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