Renal Sympathetic Denervation for the Treatment of Difficult-to-Control or Resistant Hypertension
Hypertension represents a major health problem with an appalling annual toll. Despite the plethora of antihypertensive drugs, hypertension remains resistant in a considerable number of patients, thus creating the need for alternative strategies, including interventional approaches. Recently, cathet...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.4061/2011/196518 |
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| author | Vasilios Papademetriou Michalis Doumas Konstantinos Tsioufis |
| author_facet | Vasilios Papademetriou Michalis Doumas Konstantinos Tsioufis |
| author_sort | Vasilios Papademetriou |
| collection | DOAJ |
| description | Hypertension represents a major health problem with an appalling annual toll.
Despite the plethora of antihypertensive drugs, hypertension remains resistant in a considerable number of patients, thus creating the need for alternative strategies, including interventional approaches. Recently, catheter-based renal sympathetic denervation has been shown to be fairly safe and effective in patients with resistant hypertension. Pathophysiology of kidney function, interaction and crosstalk between the kidney and the brain, justifies the use of renal sympathetic denervation in the treatment of hypertension. Data from older studies have shown that sympathectomy has effectively lowered blood pressure and prolonged life expectancy of hypertensive patients, but at considerable cost. Renal sympathetic denervation is devoid of the adverse effects of surgical sympathectomy, due to its localized
nature, is minimally invasive, and provides short procedural and recovery times. This paper outlines the pathophysiological background for renal sympathetic denervation, describes the past and the present of this interventional approach, and considers several future potential applications. |
| format | Article |
| id | doaj-art-92e77ae23c95425a92576c041cd648c9 |
| institution | Kabale University |
| issn | 2090-0392 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-92e77ae23c95425a92576c041cd648c92025-02-03T05:46:34ZengWileyInternational Journal of Hypertension2090-03922011-01-01201110.4061/2011/196518196518Renal Sympathetic Denervation for the Treatment of Difficult-to-Control or Resistant HypertensionVasilios Papademetriou0Michalis Doumas1Konstantinos Tsioufis2Veterans Affairs and Georgetown University Medical Centers, 50 Irving Street, Washington, DC 20422, USAAristotle University of Thessaloniki, Thessaloniki, GreeceNational and Kapodistrian University of Athens, Athens, GreeceHypertension represents a major health problem with an appalling annual toll. Despite the plethora of antihypertensive drugs, hypertension remains resistant in a considerable number of patients, thus creating the need for alternative strategies, including interventional approaches. Recently, catheter-based renal sympathetic denervation has been shown to be fairly safe and effective in patients with resistant hypertension. Pathophysiology of kidney function, interaction and crosstalk between the kidney and the brain, justifies the use of renal sympathetic denervation in the treatment of hypertension. Data from older studies have shown that sympathectomy has effectively lowered blood pressure and prolonged life expectancy of hypertensive patients, but at considerable cost. Renal sympathetic denervation is devoid of the adverse effects of surgical sympathectomy, due to its localized nature, is minimally invasive, and provides short procedural and recovery times. This paper outlines the pathophysiological background for renal sympathetic denervation, describes the past and the present of this interventional approach, and considers several future potential applications.http://dx.doi.org/10.4061/2011/196518 |
| spellingShingle | Vasilios Papademetriou Michalis Doumas Konstantinos Tsioufis Renal Sympathetic Denervation for the Treatment of Difficult-to-Control or Resistant Hypertension International Journal of Hypertension |
| title | Renal Sympathetic Denervation for the Treatment of Difficult-to-Control or Resistant Hypertension |
| title_full | Renal Sympathetic Denervation for the Treatment of Difficult-to-Control or Resistant Hypertension |
| title_fullStr | Renal Sympathetic Denervation for the Treatment of Difficult-to-Control or Resistant Hypertension |
| title_full_unstemmed | Renal Sympathetic Denervation for the Treatment of Difficult-to-Control or Resistant Hypertension |
| title_short | Renal Sympathetic Denervation for the Treatment of Difficult-to-Control or Resistant Hypertension |
| title_sort | renal sympathetic denervation for the treatment of difficult to control or resistant hypertension |
| url | http://dx.doi.org/10.4061/2011/196518 |
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