Dental and Periodontal Treatment Need after Dental Clearance Is Not Associated with the Outcome of Induction Therapy in Patients with Acute Leukemia: Results of a Retrospective Pilot Study
This retrospective pilot study aimed to detect whether remaining dental/periodontal treatment need and periodontal inflammation after dental clearance would be associated with the initial therapy outcome of adult patients with acute leukemia undergoing induction chemotherapy. Different parameters we...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2020/6710906 |
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| author | Gerhard Schmalz Lulzim Tulani Rilana Busjan Rainer Haak Tanja Kottmann Lorenz Trümper Justin Hasenkamp Dirk Ziebolz |
| author_facet | Gerhard Schmalz Lulzim Tulani Rilana Busjan Rainer Haak Tanja Kottmann Lorenz Trümper Justin Hasenkamp Dirk Ziebolz |
| author_sort | Gerhard Schmalz |
| collection | DOAJ |
| description | This retrospective pilot study aimed to detect whether remaining dental/periodontal treatment need and periodontal inflammation after dental clearance would be associated with the initial therapy outcome of adult patients with acute leukemia undergoing induction chemotherapy. Different parameters were assessed from the patients’ records: initial blood parameters, blood parameters during initial chemotherapy, leukemia/therapy related complaints, duration of fever, microbiological findings (blood and urine), as well as patients’ survival. Dental treatment need was defined as the presence of at least one carious tooth; periodontal treatment need was determined by the presence of probing depth ≥3.5 mm in at least two sextants. To reflect periodontal inflammation, the periodontal inflamed surface area (PISA) was applied. Thirty-nine patients were included. A dental treatment need of 75% and periodontal treatment need of 76% as well as an average PISA of 153.18 ± 158.09 were found. Only two associations were detected: periodontal treatment need was associated with thrombocyte count after 7 days (p=0.03), and PISA was associated with erythrocyte count three days after induction of therapy (p=0.01). It can be concluded that remaining dental and periodontal treatment need as well as periodontal inflammation after dental clearance is not associated with the outcome of induction therapy in adult patients with acute leukemia. |
| format | Article |
| id | doaj-art-92dbb080f7ae43d58d2780821c3fc87d |
| institution | Kabale University |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Hematology |
| spelling | doaj-art-92dbb080f7ae43d58d2780821c3fc87d2025-02-03T01:27:05ZengWileyAdvances in Hematology1687-91041687-91122020-01-01202010.1155/2020/67109066710906Dental and Periodontal Treatment Need after Dental Clearance Is Not Associated with the Outcome of Induction Therapy in Patients with Acute Leukemia: Results of a Retrospective Pilot StudyGerhard Schmalz0Lulzim Tulani1Rilana Busjan2Rainer Haak3Tanja Kottmann4Lorenz Trümper5Justin Hasenkamp6Dirk Ziebolz7Dept. of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, GermanyDept. of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, GermanyDept. of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, GermanyDept. of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, GermanyClinical Research Organization, Hamm, GermanyClinic for Hematology and Medical Oncology, University Medical Center Goettingen, Göttingen, GermanyClinic for Hematology and Medical Oncology, University Medical Center Goettingen, Göttingen, GermanyDept. of Cariology, Endodontology and Periodontology, University of Leipzig, Leipzig, GermanyThis retrospective pilot study aimed to detect whether remaining dental/periodontal treatment need and periodontal inflammation after dental clearance would be associated with the initial therapy outcome of adult patients with acute leukemia undergoing induction chemotherapy. Different parameters were assessed from the patients’ records: initial blood parameters, blood parameters during initial chemotherapy, leukemia/therapy related complaints, duration of fever, microbiological findings (blood and urine), as well as patients’ survival. Dental treatment need was defined as the presence of at least one carious tooth; periodontal treatment need was determined by the presence of probing depth ≥3.5 mm in at least two sextants. To reflect periodontal inflammation, the periodontal inflamed surface area (PISA) was applied. Thirty-nine patients were included. A dental treatment need of 75% and periodontal treatment need of 76% as well as an average PISA of 153.18 ± 158.09 were found. Only two associations were detected: periodontal treatment need was associated with thrombocyte count after 7 days (p=0.03), and PISA was associated with erythrocyte count three days after induction of therapy (p=0.01). It can be concluded that remaining dental and periodontal treatment need as well as periodontal inflammation after dental clearance is not associated with the outcome of induction therapy in adult patients with acute leukemia.http://dx.doi.org/10.1155/2020/6710906 |
| spellingShingle | Gerhard Schmalz Lulzim Tulani Rilana Busjan Rainer Haak Tanja Kottmann Lorenz Trümper Justin Hasenkamp Dirk Ziebolz Dental and Periodontal Treatment Need after Dental Clearance Is Not Associated with the Outcome of Induction Therapy in Patients with Acute Leukemia: Results of a Retrospective Pilot Study Advances in Hematology |
| title | Dental and Periodontal Treatment Need after Dental Clearance Is Not Associated with the Outcome of Induction Therapy in Patients with Acute Leukemia: Results of a Retrospective Pilot Study |
| title_full | Dental and Periodontal Treatment Need after Dental Clearance Is Not Associated with the Outcome of Induction Therapy in Patients with Acute Leukemia: Results of a Retrospective Pilot Study |
| title_fullStr | Dental and Periodontal Treatment Need after Dental Clearance Is Not Associated with the Outcome of Induction Therapy in Patients with Acute Leukemia: Results of a Retrospective Pilot Study |
| title_full_unstemmed | Dental and Periodontal Treatment Need after Dental Clearance Is Not Associated with the Outcome of Induction Therapy in Patients with Acute Leukemia: Results of a Retrospective Pilot Study |
| title_short | Dental and Periodontal Treatment Need after Dental Clearance Is Not Associated with the Outcome of Induction Therapy in Patients with Acute Leukemia: Results of a Retrospective Pilot Study |
| title_sort | dental and periodontal treatment need after dental clearance is not associated with the outcome of induction therapy in patients with acute leukemia results of a retrospective pilot study |
| url | http://dx.doi.org/10.1155/2020/6710906 |
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