Issues of Recruitment and Rationale for Conducting Clinical Trials on Mutans Streptococci Suppression in Mothers
The aims of this study are (1) to describe issues related to recruitment of mothers participating in a clinical trial of transmission of mutans streptococci (MS) from mother to child in Bauru, Brazil and (2) to perform cross-cultural and temporal comparisons of levels of infection of the MS in moth...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2010/107147 |
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| author | Walter A. Bretz Odila P. S. Rosa Salete M. B. Silva Patricia Corby Lisa Weissfeld Walter J. Loesche |
| author_facet | Walter A. Bretz Odila P. S. Rosa Salete M. B. Silva Patricia Corby Lisa Weissfeld Walter J. Loesche |
| author_sort | Walter A. Bretz |
| collection | DOAJ |
| description | The aims of this study are (1) to describe issues related to recruitment of mothers participating in a clinical trial of transmission of mutans streptococci (MS) from mother to child in Bauru, Brazil and (2) to perform cross-cultural and temporal comparisons of levels of infection of the MS in mothers of Bauru. A total of 1422 mothers were visited at their domiciles. Cutoff levels for the MS were established at ≥105 CFU/mL saliva. The main reason for a mother not enrolling was not being highly infected by the MS, yet 76% of mothers presented with levels ≥105 CFU/mL saliva. Recent studies in industrialized countries showed a negative coefficient for linear tests indicating significant decline overtime in the levels of MS in mothers. Intercountry comparisons for mothers' salivary levels of the MS with the Bauru study as the reference revealed significant differences with studies conducted in the last two decades. |
| format | Article |
| id | doaj-art-92d3f60280ff409ebf89f8cb4d71fd64 |
| institution | Kabale University |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-92d3f60280ff409ebf89f8cb4d71fd642025-02-03T06:05:08ZengWileyInternational Journal of Dentistry1687-87281687-87362010-01-01201010.1155/2010/107147107147Issues of Recruitment and Rationale for Conducting Clinical Trials on Mutans Streptococci Suppression in MothersWalter A. Bretz0Odila P. S. Rosa1Salete M. B. Silva2Patricia Corby3Lisa Weissfeld4Walter J. Loesche5College of Dentistry, New York University, NY 10010, USAFaculdade de Odontologia de Bauru, Universidade de São Paulo, 17012-901 Bauru, BrazilFaculdade de Odontologia de Bauru, Universidade de São Paulo, 17012-901 Bauru, BrazilCollege of Dentistry, New York University, NY 10010, USAGraduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USASchool of Dentistry, University of Michigan, Ann Arbor, MI 48109, USAThe aims of this study are (1) to describe issues related to recruitment of mothers participating in a clinical trial of transmission of mutans streptococci (MS) from mother to child in Bauru, Brazil and (2) to perform cross-cultural and temporal comparisons of levels of infection of the MS in mothers of Bauru. A total of 1422 mothers were visited at their domiciles. Cutoff levels for the MS were established at ≥105 CFU/mL saliva. The main reason for a mother not enrolling was not being highly infected by the MS, yet 76% of mothers presented with levels ≥105 CFU/mL saliva. Recent studies in industrialized countries showed a negative coefficient for linear tests indicating significant decline overtime in the levels of MS in mothers. Intercountry comparisons for mothers' salivary levels of the MS with the Bauru study as the reference revealed significant differences with studies conducted in the last two decades.http://dx.doi.org/10.1155/2010/107147 |
| spellingShingle | Walter A. Bretz Odila P. S. Rosa Salete M. B. Silva Patricia Corby Lisa Weissfeld Walter J. Loesche Issues of Recruitment and Rationale for Conducting Clinical Trials on Mutans Streptococci Suppression in Mothers International Journal of Dentistry |
| title | Issues of Recruitment and Rationale for Conducting Clinical Trials on Mutans Streptococci Suppression in Mothers |
| title_full | Issues of Recruitment and Rationale for Conducting Clinical Trials on Mutans Streptococci Suppression in Mothers |
| title_fullStr | Issues of Recruitment and Rationale for Conducting Clinical Trials on Mutans Streptococci Suppression in Mothers |
| title_full_unstemmed | Issues of Recruitment and Rationale for Conducting Clinical Trials on Mutans Streptococci Suppression in Mothers |
| title_short | Issues of Recruitment and Rationale for Conducting Clinical Trials on Mutans Streptococci Suppression in Mothers |
| title_sort | issues of recruitment and rationale for conducting clinical trials on mutans streptococci suppression in mothers |
| url | http://dx.doi.org/10.1155/2010/107147 |
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