Anti-angiogenic tyrosine kinase inhibitors and the pathophysiology of their toxic effects: revisiting the treatment of anemia in metastatic cancers

Anti-angiogenic tyrosine kinase inhibitors and the pathophysiology of their toxic effects: revisiting the treatment of anemia in metastatic cancers

Abstract Background Anti-angiogenic tyrosine kinase inhibitors (TKIs) have become major drugs for the treatment of various cancer types, but with an overall high incidence of severe toxicities, particularly haematological toxicities including severe anemia. Methods We treated C57BL6 mice continuousl...

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Main Authors: Tai Van Nguyen, Eurydice Angeli, Diaddin Hamdan, Morad El Bouchtaoui, Oanh T. Bui, Feriel Azibani, Rong Shen, He Lu, Kien Hung Do, Anne Janin, Quang Van Le, Guilhem Bousquet
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Experimental Hematology & Oncology
Subjects:
Anti-angiogenic agents
Tyrosine kinase inhibitor
Anemia
Sunitinib
Autophagy
Erythropoietin
Online Access:https://doi.org/10.1186/s40164-025-00640-9
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