Associations of early life per- and polyfluoroalkyl substances (PFAS) exposure with body mass index and risk of overweight or obesity at age 2–18 years: Mixture analysis in the prospective Boston Birth Cohort
Background: Per- and polyfluoroalkyl substances (PFAS) are a class of widespread persistent chemicals, which may have obesogenic effects during the fetal period. This study investigated the long-term association of maternal plasma PFAS concentrations at delivery and their mixture with child body mas...
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Elsevier
2025-01-01
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| Series: | Environment International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412024007931 |
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| author | Zeyu Li Guoying Wang Joseph M. Braun Xiumei Hong Giehae Choi Shawn P. O’Leary Chang Ho Yu Colleen Pearson William G. Adams Zhihua (Tina) Fan Jessie P. Buckley Xiaobin Wang |
| author_facet | Zeyu Li Guoying Wang Joseph M. Braun Xiumei Hong Giehae Choi Shawn P. O’Leary Chang Ho Yu Colleen Pearson William G. Adams Zhihua (Tina) Fan Jessie P. Buckley Xiaobin Wang |
| author_sort | Zeyu Li |
| collection | DOAJ |
| description | Background: Per- and polyfluoroalkyl substances (PFAS) are a class of widespread persistent chemicals, which may have obesogenic effects during the fetal period. This study investigated the long-term association of maternal plasma PFAS concentrations at delivery and their mixture with child body mass index (BMI) and the risk of Overweight or Obesity (OWO) at the age of 2–18 years. Methods: The study included 1189 mother–child dyads from the prospective Boston Birth Cohort. Eight PFAS were measured in maternal plasma samples collected 24–72 h after delivery. Outcomes were BMI Z-score and OWO status of children at 2–18 years. The exposure-outcome associations were evaluated with linear and modified Poisson mixed-effects regression for individual PFAS and Bayesian kernel machine regression and quantile-based g-computation models for PFAS mixture. We explored the effect modification by maternal pre-pregnancy OWO, child age, sex, and race. Results: Maternal plasma samples had PFAS detection frequencies from 87 % to 100 % and geometric means ranging from 0.11 to 3.67 ng/mL. PFHpS and PFHxS were associated with higher child BMI Z-score. Such associations were stronger in children aged 6–12 years and 13–18 years than in 2–5 years. Stratified by maternal pre-pregnancy OWO, significant associations of the PFAS mixture with child BMI Z-score were only found in children of non-OWO mothers. In children aged 13–18 years, children with both high maternal plasma PFDeA, PFNA, and PFOA concentrations and maternal OWO had the highest risks of OWO compared to children with either only. Such synergistic effects were not found in younger children. Conclusions: Early life exposure to individual PFAS and their mixture were associated with a higher risk of childhood OWO, with stronger associations observed in older child age groups and in children of non-OWO mothers. Synergistic effects of PFAS exposures and maternal pre-pregnancy OWO became evident in adolescence. |
| format | Article |
| id | doaj-art-9298f87408574d71907966b0f5408546 |
| institution | Kabale University |
| issn | 0160-4120 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | Environment International |
| spelling | doaj-art-9298f87408574d71907966b0f54085462025-01-24T04:44:03ZengElsevierEnvironment International0160-41202025-01-01195109206Associations of early life per- and polyfluoroalkyl substances (PFAS) exposure with body mass index and risk of overweight or obesity at age 2–18 years: Mixture analysis in the prospective Boston Birth CohortZeyu Li0Guoying Wang1Joseph M. Braun2Xiumei Hong3Giehae Choi4Shawn P. O’Leary5Chang Ho Yu6Colleen Pearson7William G. Adams8Zhihua (Tina) Fan9Jessie P. Buckley10Xiaobin Wang11Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USACenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USADepartment of Epidemiology, Brown University, Providence, RI, USACenter on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USADepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USAEnvironmental and Chemical Laboratory Services, Public Health and Environmental Laboratories, New Jersey Department of Health, Trenton, NJ, USAEnvironmental and Chemical Laboratory Services, Public Health and Environmental Laboratories, New Jersey Department of Health, Trenton, NJ, USADepartment of Pediatrics, Boston University Chobanian and Avedisian School of Medicine and Boston Medical Center, Boston, MA, USADepartment of Pediatrics, Boston University Chobanian and Avedisian School of Medicine and Boston Medical Center, Boston, MA, USAEnvironmental and Chemical Laboratory Services, Public Health and Environmental Laboratories, New Jersey Department of Health, Trenton, NJ, USADepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Corresponding author at: Department of Epidemiology, University of North Carolina at Chapel Hill, McGavran-Greenberg Hall CB#7435, 2106-B, Chapel Hill, NC 27599, USA.Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD, USA; Corresponding author at: Center on the Early Life Origins of Disease, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, E4132, Baltimore, MD 21205, USA.Background: Per- and polyfluoroalkyl substances (PFAS) are a class of widespread persistent chemicals, which may have obesogenic effects during the fetal period. This study investigated the long-term association of maternal plasma PFAS concentrations at delivery and their mixture with child body mass index (BMI) and the risk of Overweight or Obesity (OWO) at the age of 2–18 years. Methods: The study included 1189 mother–child dyads from the prospective Boston Birth Cohort. Eight PFAS were measured in maternal plasma samples collected 24–72 h after delivery. Outcomes were BMI Z-score and OWO status of children at 2–18 years. The exposure-outcome associations were evaluated with linear and modified Poisson mixed-effects regression for individual PFAS and Bayesian kernel machine regression and quantile-based g-computation models for PFAS mixture. We explored the effect modification by maternal pre-pregnancy OWO, child age, sex, and race. Results: Maternal plasma samples had PFAS detection frequencies from 87 % to 100 % and geometric means ranging from 0.11 to 3.67 ng/mL. PFHpS and PFHxS were associated with higher child BMI Z-score. Such associations were stronger in children aged 6–12 years and 13–18 years than in 2–5 years. Stratified by maternal pre-pregnancy OWO, significant associations of the PFAS mixture with child BMI Z-score were only found in children of non-OWO mothers. In children aged 13–18 years, children with both high maternal plasma PFDeA, PFNA, and PFOA concentrations and maternal OWO had the highest risks of OWO compared to children with either only. Such synergistic effects were not found in younger children. Conclusions: Early life exposure to individual PFAS and their mixture were associated with a higher risk of childhood OWO, with stronger associations observed in older child age groups and in children of non-OWO mothers. Synergistic effects of PFAS exposures and maternal pre-pregnancy OWO became evident in adolescence.http://www.sciencedirect.com/science/article/pii/S0160412024007931PFASChildhood overweight or obesityBMIMaternal overweight or obesityDOHaD theoryPrenatal exposure |
| spellingShingle | Zeyu Li Guoying Wang Joseph M. Braun Xiumei Hong Giehae Choi Shawn P. O’Leary Chang Ho Yu Colleen Pearson William G. Adams Zhihua (Tina) Fan Jessie P. Buckley Xiaobin Wang Associations of early life per- and polyfluoroalkyl substances (PFAS) exposure with body mass index and risk of overweight or obesity at age 2–18 years: Mixture analysis in the prospective Boston Birth Cohort Environment International PFAS Childhood overweight or obesity BMI Maternal overweight or obesity DOHaD theory Prenatal exposure |
| title | Associations of early life per- and polyfluoroalkyl substances (PFAS) exposure with body mass index and risk of overweight or obesity at age 2–18 years: Mixture analysis in the prospective Boston Birth Cohort |
| title_full | Associations of early life per- and polyfluoroalkyl substances (PFAS) exposure with body mass index and risk of overweight or obesity at age 2–18 years: Mixture analysis in the prospective Boston Birth Cohort |
| title_fullStr | Associations of early life per- and polyfluoroalkyl substances (PFAS) exposure with body mass index and risk of overweight or obesity at age 2–18 years: Mixture analysis in the prospective Boston Birth Cohort |
| title_full_unstemmed | Associations of early life per- and polyfluoroalkyl substances (PFAS) exposure with body mass index and risk of overweight or obesity at age 2–18 years: Mixture analysis in the prospective Boston Birth Cohort |
| title_short | Associations of early life per- and polyfluoroalkyl substances (PFAS) exposure with body mass index and risk of overweight or obesity at age 2–18 years: Mixture analysis in the prospective Boston Birth Cohort |
| title_sort | associations of early life per and polyfluoroalkyl substances pfas exposure with body mass index and risk of overweight or obesity at age 2 18 years mixture analysis in the prospective boston birth cohort |
| topic | PFAS Childhood overweight or obesity BMI Maternal overweight or obesity DOHaD theory Prenatal exposure |
| url | http://www.sciencedirect.com/science/article/pii/S0160412024007931 |
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