Discovery of a novel binding pocket in PPARγ for partial agonists: structure-based virtual screening identifies ginsenoside Rg5 as a partial agonist promoting beige adipogenesis

Discovery of a novel binding pocket in PPARγ for partial agonists: structure-based virtual screening identifies ginsenoside Rg5 as a partial agonist promoting beige adipogenesis

Peroxisome proliferator-activated receptor gamma (PPARγ) is a key target for metabolic disorders that contribute to obesity and type 2 diabetes mellitus (T2DM). However, full agonists such as thiazolidinediones (TZDs) have limitations in terms of side effects. Selective PPARγ modulators (SPPARγMs) t...

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Bibliographic Details
Main Authors: Zhen Wang, Kexin Shui, Zehui Zhang, Yihan Chen, Nanfei Yang, Shiliang Ji, Pingping Shen, Qiang Tian
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Chemistry
Subjects:
PPARγ
binding pocket
natural product
virtual screening
beige cells
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2025.1579445/full
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