Small-Cell Lung Cancer with Positive Anti-NMDAR and Anti-AMPAR Antibodies Paraneoplastic Limbic Encephalitis
We report the case of a 66-year-old woman, with paraneoplastic limbic encephalitis, treated 6 months earlier for bladder neoplasia. The patient presented to the emergency room with rapidly increasing symptoms, noninfectious cerebral spinal fluid associated with positive anti-NMDAR (as well as in ser...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Neurological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/3263718 |
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| author | Sabina Boangher Pascal Mespouille Corina-Mihaela Filip Sophie Goffette |
| author_facet | Sabina Boangher Pascal Mespouille Corina-Mihaela Filip Sophie Goffette |
| author_sort | Sabina Boangher |
| collection | DOAJ |
| description | We report the case of a 66-year-old woman, with paraneoplastic limbic encephalitis, treated 6 months earlier for bladder neoplasia. The patient presented to the emergency room with rapidly increasing symptoms, noninfectious cerebral spinal fluid associated with positive anti-NMDAR (as well as in serum) and positive AMPAR antibodies in the serum. Four months later, the patient was diagnosed with a small-cell lung cancer for which chemotherapy and radiotherapy was commenced. Simultaneously, endoscopic surgical treatment was undertaken for an in situ relapse of the bladder neoplasm. After the completion of 3 cycles of chemotherapy her neurological status temporarily worsened. The cerebral MRI did not show signs of encephalitis such as increased T2/FLAIR signal intensity in the mesial temporal lobes and limbic systems. No specific treatment was prescribed. Limbic encephalitis can be associated with malignant tumors such as lung carcinoma. Several cases reported in the literature have shown cognitive improvement after tumoral therapy. Regarding our experience, significant progress was achieved through immuno-modulatory treatment. A transitory deterioration of the cognitive process was perceived during the chemotherapy sessions. |
| format | Article |
| id | doaj-art-927cc45e21f248efa4706ba7a5a5a17d |
| institution | Kabale University |
| issn | 2090-6668 2090-6676 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Neurological Medicine |
| spelling | doaj-art-927cc45e21f248efa4706ba7a5a5a17d2025-02-03T05:51:00ZengWileyCase Reports in Neurological Medicine2090-66682090-66762016-01-01201610.1155/2016/32637183263718Small-Cell Lung Cancer with Positive Anti-NMDAR and Anti-AMPAR Antibodies Paraneoplastic Limbic EncephalitisSabina Boangher0Pascal Mespouille1Corina-Mihaela Filip2Sophie Goffette3Department of Neurology, Arlon Hospital, No. 137, Rue des Déportés, 6700 Arlon, BelgiumDepartment of Neurology, Arlon Hospital, No. 137, Rue des Déportés, 6700 Arlon, BelgiumOncology Department, CH Luxembourg, Rue Nicolas-Ernest Barblé, No. 4, L 1210 Luxembourg, LuxembourgDepartment of Neurology, Arlon Hospital, No. 137, Rue des Déportés, 6700 Arlon, BelgiumWe report the case of a 66-year-old woman, with paraneoplastic limbic encephalitis, treated 6 months earlier for bladder neoplasia. The patient presented to the emergency room with rapidly increasing symptoms, noninfectious cerebral spinal fluid associated with positive anti-NMDAR (as well as in serum) and positive AMPAR antibodies in the serum. Four months later, the patient was diagnosed with a small-cell lung cancer for which chemotherapy and radiotherapy was commenced. Simultaneously, endoscopic surgical treatment was undertaken for an in situ relapse of the bladder neoplasm. After the completion of 3 cycles of chemotherapy her neurological status temporarily worsened. The cerebral MRI did not show signs of encephalitis such as increased T2/FLAIR signal intensity in the mesial temporal lobes and limbic systems. No specific treatment was prescribed. Limbic encephalitis can be associated with malignant tumors such as lung carcinoma. Several cases reported in the literature have shown cognitive improvement after tumoral therapy. Regarding our experience, significant progress was achieved through immuno-modulatory treatment. A transitory deterioration of the cognitive process was perceived during the chemotherapy sessions.http://dx.doi.org/10.1155/2016/3263718 |
| spellingShingle | Sabina Boangher Pascal Mespouille Corina-Mihaela Filip Sophie Goffette Small-Cell Lung Cancer with Positive Anti-NMDAR and Anti-AMPAR Antibodies Paraneoplastic Limbic Encephalitis Case Reports in Neurological Medicine |
| title | Small-Cell Lung Cancer with Positive Anti-NMDAR and Anti-AMPAR Antibodies Paraneoplastic Limbic Encephalitis |
| title_full | Small-Cell Lung Cancer with Positive Anti-NMDAR and Anti-AMPAR Antibodies Paraneoplastic Limbic Encephalitis |
| title_fullStr | Small-Cell Lung Cancer with Positive Anti-NMDAR and Anti-AMPAR Antibodies Paraneoplastic Limbic Encephalitis |
| title_full_unstemmed | Small-Cell Lung Cancer with Positive Anti-NMDAR and Anti-AMPAR Antibodies Paraneoplastic Limbic Encephalitis |
| title_short | Small-Cell Lung Cancer with Positive Anti-NMDAR and Anti-AMPAR Antibodies Paraneoplastic Limbic Encephalitis |
| title_sort | small cell lung cancer with positive anti nmdar and anti ampar antibodies paraneoplastic limbic encephalitis |
| url | http://dx.doi.org/10.1155/2016/3263718 |
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