P-ANCA Systemic Vasculitis Induced by Brucellosis in an Elderly Male Patient
One of the most prevalent causes of vasculitis is bacterial infection. An infection that causes anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is uncommon and not reported frequently. We report a case of a 74-year-old male who presented with fever for ten days and was found...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Rheumatology |
| Online Access: | http://dx.doi.org/10.1155/2021/6117671 |
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| author | Mohammed Cheikh Abdulrahman Kabli Esraa Sendi Hani Almoallim |
| author_facet | Mohammed Cheikh Abdulrahman Kabli Esraa Sendi Hani Almoallim |
| author_sort | Mohammed Cheikh |
| collection | DOAJ |
| description | One of the most prevalent causes of vasculitis is bacterial infection. An infection that causes anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is uncommon and not reported frequently. We report a case of a 74-year-old male who presented with fever for ten days and was found to have brucellosis. Then, he was diagnosed with Guillain-Barré syndrome (GBS) and started on immunoglobulin (IVIG) for one week without a response. His fever was still persistent despite appropriate antibiotic therapy. Rheumatology evaluation revealed a history of multiple joint pain and swelling, elevated inflammatory marker, and a high titer of P-ANCA. Steroid therapy was started initially on the background of antibiotics therapy. His fever and other symptoms showed marked improvement after one week. However, P-ANCA titer was still elevated. The decision was made to treat the patient as a case of brucellosis-induced P-ANCA vasculitis. Azathioprine was added, and steroid was maintained for one month and then it was tapered gradually. All symptoms improved from the third month of follow-up except weakness from peripheral neuropathy with normalization of P-ANCA titer. His condition remained stable after six months of follow-up. Clinicians should be aware of the possibility of infection-induced vasculitis, particularly when patients’ symptoms persist despite the appropriate use of antibiotics. |
| format | Article |
| id | doaj-art-927479c8f5a942ffb3601b57254ea0f6 |
| institution | Kabale University |
| issn | 2090-6897 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Rheumatology |
| spelling | doaj-art-927479c8f5a942ffb3601b57254ea0f62025-02-03T01:10:53ZengWileyCase Reports in Rheumatology2090-68972021-01-01202110.1155/2021/6117671P-ANCA Systemic Vasculitis Induced by Brucellosis in an Elderly Male PatientMohammed Cheikh0Abdulrahman Kabli1Esraa Sendi2Hani Almoallim3Department of MedicineDepartment of MedicineDepartment of MedicineDepartment of MedicineOne of the most prevalent causes of vasculitis is bacterial infection. An infection that causes anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is uncommon and not reported frequently. We report a case of a 74-year-old male who presented with fever for ten days and was found to have brucellosis. Then, he was diagnosed with Guillain-Barré syndrome (GBS) and started on immunoglobulin (IVIG) for one week without a response. His fever was still persistent despite appropriate antibiotic therapy. Rheumatology evaluation revealed a history of multiple joint pain and swelling, elevated inflammatory marker, and a high titer of P-ANCA. Steroid therapy was started initially on the background of antibiotics therapy. His fever and other symptoms showed marked improvement after one week. However, P-ANCA titer was still elevated. The decision was made to treat the patient as a case of brucellosis-induced P-ANCA vasculitis. Azathioprine was added, and steroid was maintained for one month and then it was tapered gradually. All symptoms improved from the third month of follow-up except weakness from peripheral neuropathy with normalization of P-ANCA titer. His condition remained stable after six months of follow-up. Clinicians should be aware of the possibility of infection-induced vasculitis, particularly when patients’ symptoms persist despite the appropriate use of antibiotics.http://dx.doi.org/10.1155/2021/6117671 |
| spellingShingle | Mohammed Cheikh Abdulrahman Kabli Esraa Sendi Hani Almoallim P-ANCA Systemic Vasculitis Induced by Brucellosis in an Elderly Male Patient Case Reports in Rheumatology |
| title | P-ANCA Systemic Vasculitis Induced by Brucellosis in an Elderly Male Patient |
| title_full | P-ANCA Systemic Vasculitis Induced by Brucellosis in an Elderly Male Patient |
| title_fullStr | P-ANCA Systemic Vasculitis Induced by Brucellosis in an Elderly Male Patient |
| title_full_unstemmed | P-ANCA Systemic Vasculitis Induced by Brucellosis in an Elderly Male Patient |
| title_short | P-ANCA Systemic Vasculitis Induced by Brucellosis in an Elderly Male Patient |
| title_sort | p anca systemic vasculitis induced by brucellosis in an elderly male patient |
| url | http://dx.doi.org/10.1155/2021/6117671 |
| work_keys_str_mv | AT mohammedcheikh pancasystemicvasculitisinducedbybrucellosisinanelderlymalepatient AT abdulrahmankabli pancasystemicvasculitisinducedbybrucellosisinanelderlymalepatient AT esraasendi pancasystemicvasculitisinducedbybrucellosisinanelderlymalepatient AT hanialmoallim pancasystemicvasculitisinducedbybrucellosisinanelderlymalepatient |