Antenatal Steroid Therapy for Fetal Lung Maturation and the Subsequent Risk of Childhood Asthma: A Longitudinal Analysis
This study was designed to test the hypothesis that fetal exposure to corticosteroids in the antenatal period is an independent risk factor for the development of asthma in early childhood with little or no effect in later childhood. A population-based cohort study of all pregnant women who resided...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Pregnancy |
| Online Access: | http://dx.doi.org/10.1155/2010/789748 |
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| author | Jason D. Pole Cameron A. Mustard Teresa To Joseph Beyene Alexander C. Allen |
| author_facet | Jason D. Pole Cameron A. Mustard Teresa To Joseph Beyene Alexander C. Allen |
| author_sort | Jason D. Pole |
| collection | DOAJ |
| description | This study was designed to test the hypothesis that fetal exposure to corticosteroids in the antenatal period is an independent risk factor for the development of asthma in early childhood with little or no effect in later childhood. A population-based cohort study of all pregnant women who resided in Nova Scotia, Canada, and gave birth to a singleton fetus between 1989 and 1998
was undertaken. After a priori specified exclusions, 80,448 infants were available for analysis.
Using linked health care utilization records, incident asthma cases developed after 36 months of
age were identified. Extended Cox proportional hazards models were used to estimate hazard
ratios while controlling for confounders. Exposure to corticosteroids during pregnancy was
associated with a risk of asthma in childhood between 3–5 years of age: adjusted hazard ratio of
1.19 (95% confidence interval: 1.03, 1.39), with no association noted after 5 years of age:
adjusted hazard ratio for 5–7 years was 1.06 (95% confidence interval: 0.86, 1.30)
and for 8 or greater years was 0.74 (95% confidence interval: 0.54, 1.03). Antenatal steroid therapy appears to be an independent risk factor for the development of asthma between 3 and 5 years of age. |
| format | Article |
| id | doaj-art-925beb6e0c9b423c97f9eba45ec6c590 |
| institution | Kabale University |
| issn | 2090-2727 2090-2735 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Pregnancy |
| spelling | doaj-art-925beb6e0c9b423c97f9eba45ec6c5902025-02-03T06:00:35ZengWileyJournal of Pregnancy2090-27272090-27352010-01-01201010.1155/2010/789748789748Antenatal Steroid Therapy for Fetal Lung Maturation and the Subsequent Risk of Childhood Asthma: A Longitudinal AnalysisJason D. Pole0Cameron A. Mustard1Teresa To2Joseph Beyene3Alexander C. Allen4Dalla Lana School of Public Health, University of Toronto, Toronto, ON, M5T 3M7, CanadaDalla Lana School of Public Health, University of Toronto, Toronto, ON, M5T 3M7, CanadaDalla Lana School of Public Health, University of Toronto, Toronto, ON, M5T 3M7, CanadaDalla Lana School of Public Health, University of Toronto, Toronto, ON, M5T 3M7, CanadaPerinatal Epidemiology Research Unit, Departments of Obstetrics and Gynecology and Pediatrics, Dalhousie University, Halifax, Nova Scotia, B3K 6R8, CanadaThis study was designed to test the hypothesis that fetal exposure to corticosteroids in the antenatal period is an independent risk factor for the development of asthma in early childhood with little or no effect in later childhood. A population-based cohort study of all pregnant women who resided in Nova Scotia, Canada, and gave birth to a singleton fetus between 1989 and 1998 was undertaken. After a priori specified exclusions, 80,448 infants were available for analysis. Using linked health care utilization records, incident asthma cases developed after 36 months of age were identified. Extended Cox proportional hazards models were used to estimate hazard ratios while controlling for confounders. Exposure to corticosteroids during pregnancy was associated with a risk of asthma in childhood between 3–5 years of age: adjusted hazard ratio of 1.19 (95% confidence interval: 1.03, 1.39), with no association noted after 5 years of age: adjusted hazard ratio for 5–7 years was 1.06 (95% confidence interval: 0.86, 1.30) and for 8 or greater years was 0.74 (95% confidence interval: 0.54, 1.03). Antenatal steroid therapy appears to be an independent risk factor for the development of asthma between 3 and 5 years of age.http://dx.doi.org/10.1155/2010/789748 |
| spellingShingle | Jason D. Pole Cameron A. Mustard Teresa To Joseph Beyene Alexander C. Allen Antenatal Steroid Therapy for Fetal Lung Maturation and the Subsequent Risk of Childhood Asthma: A Longitudinal Analysis Journal of Pregnancy |
| title | Antenatal Steroid Therapy for Fetal Lung Maturation and the Subsequent Risk of Childhood Asthma: A Longitudinal Analysis |
| title_full | Antenatal Steroid Therapy for Fetal Lung Maturation and the Subsequent Risk of Childhood Asthma: A Longitudinal Analysis |
| title_fullStr | Antenatal Steroid Therapy for Fetal Lung Maturation and the Subsequent Risk of Childhood Asthma: A Longitudinal Analysis |
| title_full_unstemmed | Antenatal Steroid Therapy for Fetal Lung Maturation and the Subsequent Risk of Childhood Asthma: A Longitudinal Analysis |
| title_short | Antenatal Steroid Therapy for Fetal Lung Maturation and the Subsequent Risk of Childhood Asthma: A Longitudinal Analysis |
| title_sort | antenatal steroid therapy for fetal lung maturation and the subsequent risk of childhood asthma a longitudinal analysis |
| url | http://dx.doi.org/10.1155/2010/789748 |
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