Liver Cirrhosis: Evaluation, Nutritional Status, and Prognosis
The liver is the major organ for the metabolism of three major nutrients: protein, fat, and carbohydrate. Chronic hepatitis C virus infection is the major cause of chronic liver disease. Liver cirrhosis (LC) results from different mechanisms of liver injury that lead to necroinflammation and fibrosi...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/872152 |
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| author | Hiroki Nishikawa Yukio Osaki |
| author_facet | Hiroki Nishikawa Yukio Osaki |
| author_sort | Hiroki Nishikawa |
| collection | DOAJ |
| description | The liver is the major organ for the metabolism of three major nutrients: protein, fat, and carbohydrate. Chronic hepatitis C virus infection is the major cause of chronic liver disease. Liver cirrhosis (LC) results from different mechanisms of liver injury that lead to necroinflammation and fibrosis. LC has been seen to be not a single disease entity but one that can be graded into distinct clinical stages related to clinical outcome. Several noninvasive methods have been developed for assessing liver fibrosis and these methods have been used for predicting prognosis in patients with LC. On the other hand, subjects with LC often have protein-energy malnutrition (PEM) and poor physical activity. These conditions often result in sarcopenia, which is the loss of skeletal muscle volume and increased muscle weakness. Recent studies have demonstrated that PEM and sarcopenia are predictive factors for poorer survival in patients with LC. Based on these backgrounds, several methods for evaluating nutritional status in patients with chronic liver disease have been developed and they have been preferably used in the clinical field practice. In this review, we will summarize the current knowledge in the field of LC from the viewpoints of diagnostic method, nutritional status, and clinical outcomes. |
| format | Article |
| id | doaj-art-924f7a7ea1fb4ac3bf2fcf47c0b6b69c |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-924f7a7ea1fb4ac3bf2fcf47c0b6b69c2025-02-03T00:59:51ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/872152872152Liver Cirrhosis: Evaluation, Nutritional Status, and PrognosisHiroki Nishikawa0Yukio Osaki1Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka, JapanDepartment of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka, JapanThe liver is the major organ for the metabolism of three major nutrients: protein, fat, and carbohydrate. Chronic hepatitis C virus infection is the major cause of chronic liver disease. Liver cirrhosis (LC) results from different mechanisms of liver injury that lead to necroinflammation and fibrosis. LC has been seen to be not a single disease entity but one that can be graded into distinct clinical stages related to clinical outcome. Several noninvasive methods have been developed for assessing liver fibrosis and these methods have been used for predicting prognosis in patients with LC. On the other hand, subjects with LC often have protein-energy malnutrition (PEM) and poor physical activity. These conditions often result in sarcopenia, which is the loss of skeletal muscle volume and increased muscle weakness. Recent studies have demonstrated that PEM and sarcopenia are predictive factors for poorer survival in patients with LC. Based on these backgrounds, several methods for evaluating nutritional status in patients with chronic liver disease have been developed and they have been preferably used in the clinical field practice. In this review, we will summarize the current knowledge in the field of LC from the viewpoints of diagnostic method, nutritional status, and clinical outcomes.http://dx.doi.org/10.1155/2015/872152 |
| spellingShingle | Hiroki Nishikawa Yukio Osaki Liver Cirrhosis: Evaluation, Nutritional Status, and Prognosis Mediators of Inflammation |
| title | Liver Cirrhosis: Evaluation, Nutritional Status, and Prognosis |
| title_full | Liver Cirrhosis: Evaluation, Nutritional Status, and Prognosis |
| title_fullStr | Liver Cirrhosis: Evaluation, Nutritional Status, and Prognosis |
| title_full_unstemmed | Liver Cirrhosis: Evaluation, Nutritional Status, and Prognosis |
| title_short | Liver Cirrhosis: Evaluation, Nutritional Status, and Prognosis |
| title_sort | liver cirrhosis evaluation nutritional status and prognosis |
| url | http://dx.doi.org/10.1155/2015/872152 |
| work_keys_str_mv | AT hirokinishikawa livercirrhosisevaluationnutritionalstatusandprognosis AT yukioosaki livercirrhosisevaluationnutritionalstatusandprognosis |