Clinical Efficacy of Canrenone in Restoring Sinus Rhythm in Patients With Atrial Fibrillation—A Pilot, Randomized, Double-Blind Study

Clinical Efficacy of Canrenone in Restoring Sinus Rhythm in Patients With Atrial Fibrillation—A Pilot, Randomized, Double-Blind Study

Background and aims Renin-angiotensin-aldosterone system (RAAS) inhibition is an upstream therapy for managing atrial fibrillation (AF). Of all RAAS-inhibiting agents, only canrenone in the form of potassium canrenoate, a specific inhibitor of mineralocorticoid receptors, is administered intravenous...

Full description

Saved in:

Bibliographic Details
Main Authors:	Rafał Dąbrowski MD, PhD, Agnieszka Segiet-Święcicka MD, PhD, Stefan Sawicki MD, PhD, Ilona Kowalik MD, PhD, Krzysztof Jaworski MD, PhD, Michał Farkowski MD, PhD, Agata Kubaszek-Kornatowska MD, PhD, Piotr Michałek MD, PhD, Mirosław Dłużniewski MD, PhD, Hanna Szwed MD, PhD, Tomasz Hryniewiecki MD, PhD, Jarosław Karwowski PhD
Format:	Article
Language:	English
Published:	SAGE Publishing 2025-07-01
Series:	Journal of Cardiovascular Pharmacology and Therapeutics
Online Access:	https://doi.org/10.1177/10742484251356361
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Post-discontinuation Survival in Patients With Advanced NSCLC Receiving Immune Checkpoint Inhibitors: A Pooled Analysis of Prospective Cohort Studies
by: Yusuke Inoue, MD, PhD, et al.
Published: (2025-08-01)

Intensity-Modulated Radiotherapy for Locally Advanced Lung Cancer in the Immunotherapy Era: A Prospective Study WJOG12019L
by: Hideyuki Harada, MD, PhD, et al.
Published: (2025-06-01)

Independent association of a 17q21 variant with exacerbations in type 2–low adult asthma
by: Yumi Ishiyama, MD, et al.
Published: (2025-08-01)

A Phase I/II Study of Ultra-Hypofractionated Carbon-ion Radiation therapy for Low- and Intermediate-Risk Localized Prostate Cancer
by: Noriyuki Okonogi, MD, PhD, et al.
Published: (2025-03-01)

Neoadjuvant Chemotherapy Versus Adjuvant Chemotherapy for Very Low-Lying Clinical T3 Rectal Cancer: The NAIR Phase 2/3 Randomized Clinical Trial
by: Yuichiro Tsukada, MD, PhD, et al.
Published: (2025-06-01)

Nonneutralizing antibodies in Nordic persons with moderate hemophilia A and B (the MoHem study)
by: Ragnhild J. Måseide, MD, PhD, et al.
Published: (2024-11-01)

Extended segmentectomy for intersegmental lesions with intraoperative surgical margin assessment by radiofrequency identification markersCentral MessagePerspective
by: Yojiro Yutaka, MD, PhD, et al.
Published: (2024-12-01)

Complete Resection of Mediastinal Undifferentiated Pleomorphic Sarcoma
by: Ryusuke Sumiya, MD, PhD, et al.
Published: (2025-03-01)

Graft-Versus-Host Disease Sustains Coagulation Activity for two Years After Pediatric Allogeneic Hematopoietic Stem Cell Transplantation
by: Satu Långström MD, PhD, et al.
Published: (2025-02-01)

Patients’ Trajectory With Lung Cancer From Treatment Initiation to End-Of-Life: A Retrospective Cohort Study Using Claims Data in Japan
by: Yuri Ogura MD, et al.
Published: (2024-11-01)

Characterization of Malnutrition in Atrial Functional Mitral Regurgitation
by: Tsukasa Murakami, MD, PhD, et al.
Published: (2025-08-01)

Deep Learning-Based Identification of Echocardiographic Abnormalities From Electrocardiograms
by: Goro Fujiki, MD, et al.
Published: (2025-01-01)

B-cell immunodeficiency associated with polynucleotide kinase 3′-phosphatase (PNKP) deficiency
by: Sanami Takada, MD, PhD, et al.
Published: (2025-08-01)

Feasibility study of a novel wireless localization technique using radiofrequency identification markers for small and deeply located lung lesionsCentral MessagePerspective
by: Yojiro Yutaka, MD, PhD, et al.
Published: (2022-04-01)

Three-step surgical management algorithm for annular rupture in transcatheter aortic valve replacementCentral MessagePerspective
by: Kizuku Yamashita, MD, PhD, et al.
Published: (2023-12-01)

Secondary Revision after Breast Reconstruction with Free Abdominal Perforator Flap: Flap Liposuction and Inframammary Fold Reconstruction
by: Seiko Okumura, MD, PhD, et al.
Published: (2024-12-01)

Phase 2 Trial of Combination Radiotherapy and Pembrolizumab Plus Chemotherapy in Patients With Previously Untreated Metastatic NSCLC: NJLCG 1902
by: Yoko Tsukita, MD, PhD, et al.
Published: (2025-05-01)

Significance of Normal Lung Volume on Quantitative CT Imaging Analysis in Group 1 and Group 3 Pulmonary HypertensionTake-home Points
by: Tadasu Okaya, MD. PhD, et al.
Published: (2024-12-01)

High-Dose Direct Irradiation to a Cardiac Resynchronization Therapy Defibrillator Infiltrated by Metastatic Thyroid Papillary Carcinoma in the Sternum: A Case Report
by: Masaaki Goto, MD, et al.
Published: (2025-01-01)

EGFR-Mutated Lung Adenocarcinoma With Li–Fraumeni Syndrome: The Imperative for Germline Testing in Patients With a Family History, a Case Report
by: Hiroyuki Fujii, MD, et al.
Published: (2025-02-01)

A prospective study of a training program for bronchial sleeve resection using operable 3-dimensional modelsCentral MessagePerspective
by: Kohei Hashimoto, MD, PhD, et al.
Published: (2024-10-01)

Spontaneous cervical and mediastinal hematoma due to rupture of inferior thyroid artery
by: Takayuki Yamada, MD, PhD, et al.
Published: (2025-02-01)

Impact of 2018 Japan floods on allergic rhinitis prescriptions
by: Hanae Konishi, MD, et al.
Published: (2025-05-01)

Assessment of effectiveness and safety of thrombolytic therapy to pulmonary emboli by endobronchial ultrasound-guided transbronchial needle injectionCentral MessagePerspective
by: Yuki Sata, MD, PhD, et al.
Published: (2023-12-01)

Elevated mepolizumab levels in patients with severe asthma responsive to 1 year’s mepolizumab treatment
by: Takayasu Nishimaki, MD, et al.
Published: (2025-05-01)

A feasible technique for distinguishing the intersegmental plane by transbronchial injection of iron sucroseCentral MessagePerspective
by: Chengqiang Li, MD, PhD, et al.
Published: (2023-04-01)

ChatGPT-4 Responses on Ankle Cartilage Surgery Often Diverge from Expert Consensus: A Comparative Analysis
by: Takuji Yokoe MD, PhD, et al.
Published: (2025-08-01)

Loop technique with ink-dot marking test: An alternative strategy to the ink testCentral MessagePerspective
by: Akimasa Morisaki, MD, PhD, et al.
Published: (2020-09-01)

Treatment With an Osteochondral Graft From the Olecranon for a Fernandez Classification Type 4 Distal Radial Fracture
by: Yusuke Yuasa, MD, PhD, et al.
Published: (2025-05-01)

Lumbosacral Plexopathy After Carbon-ion Radiation Therapy for Postoperative Pelvic Recurrence of Rectal Cancer: Subanalysis of a Prospective Observational Study (GUNMA 0801)
by: Takuya Kumazawa, MD, PhD, et al.
Published: (2025-03-01)

Surgical techniques for robotic portal complex sleeve resection of the left lower lobe and lingulaCentral Message
by: Shinsuke Uchida, MD, PhD, et al.
Published: (2025-08-01)

Successful Emergency Transcatheter Aortic Valve Replacement for Severe Aortic Regurgitation in Takayasu’s Arteritis
by: Takanori Kawamoto, MD, PhD, et al.
Published: (2025-07-01)

Pembrolizumab and Pemetrexed for Older Patients With Nonsquamous NSCLC and Programmed Cell Death-Ligand 1 Tumor Proportion Scores of Less Than 50%
by: Yoshihito Kogure, MD, PhD, et al.
Published: (2025-03-01)

Surgical treatment of a large portopulmonary venous anastomosis in a patient with portal vein thrombosisCentral Message
by: Takahiro Ochi, MD, et al.
Published: (2024-02-01)

Consensus from European experts on severe eosinophilic asthma and chronic rhinosinusitis with nasal polyps: Results from the OverSEA Delphi study
by: Claus Bachert, MD, PhD, et al.
Published: (2025-11-01)

Preservation of Graft Kidney with De Novo Pelvic Urothelial Carcinoma Via Stereotactic Body Radiation Therapy: A Case Report
by: Koyo Kikuchi, MD, PhD, et al.
Published: (2025-09-01)

Immune Checkpoint Inhibitors in Kidney Transplant Recipients: A French Multicenter Retrospective Cohort Study
by: Tristan Legris, MD, et al.
Published: (2025-09-01)

Efficacy of Combined Use of PELNAC and Platelet-rich Plasma in Promoting Wound Healing
by: Hiroshi Fujimaki, MD, PhD, et al.
Published: (2025-08-01)

Relationship between preoperative body composition parameters and postoperative clinical score for rotator cuff tear patients
by: Naoki Takatori, MD, PhD, et al.
Published: (2025-07-01)

Benefits of Expert Online Consultations for the Detection of Pulmonary Embolism and Timely Treatment: Enhancing Telemedicine Technology–A Case ReportNovel Teaching Points
by: Masaki Takenaka, MD, PhD, et al.
Published: (2025-08-01)