Role of Inflammation in Muscle Homeostasis and Myogenesis
Skeletal muscle mass is subject to rapid changes according to growth stimuli inducing both hypertrophy, through increased protein synthesis, and hyperplasia, activating the myogenic program. Muscle wasting, characteristic of several pathological states associated with local or systemic inflammation,...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/805172 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832545317827903488 |
|---|---|
| author | Domiziana Costamagna Paola Costelli Maurilio Sampaolesi Fabio Penna |
| author_facet | Domiziana Costamagna Paola Costelli Maurilio Sampaolesi Fabio Penna |
| author_sort | Domiziana Costamagna |
| collection | DOAJ |
| description | Skeletal muscle mass is subject to rapid changes according to growth stimuli inducing both hypertrophy, through increased protein synthesis, and hyperplasia, activating the myogenic program. Muscle wasting, characteristic of several pathological states associated with local or systemic inflammation, has been for long considered to rely on the alteration of myofiber intracellular pathways regulated by both hormones and cytokines, eventually leading to impaired anabolism and increased protein breakdown. However, there are increasing evidences that even alterations of the myogenic/regenerative program play a role in the onset of muscle wasting, even though the precise mechanisms involved are far from being fully elucidated. The comprehension of the links potentially occurring between impaired myogenesis and increased catabolism would allow the definition of effective strategies aimed at counteracting muscle wasting. The first part of this review gives an overview of skeletal muscle intracellular pathways determining fiber size, while the second part considers the cells and the regulatory pathways involved in the myogenic program. In both parts are discussed the evidences supporting the role of inflammation in impairing muscle homeostasis and myogenesis, potentially determining muscle atrophy. |
| format | Article |
| id | doaj-art-9235fce8c7c0498d9834283809a4ca9e |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-9235fce8c7c0498d9834283809a4ca9e2025-02-03T07:26:06ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/805172805172Role of Inflammation in Muscle Homeostasis and MyogenesisDomiziana Costamagna0Paola Costelli1Maurilio Sampaolesi2Fabio Penna3Department of Clinical and Biological Sciences, University of Torino, 10125 Torino, ItalyDepartment of Clinical and Biological Sciences, University of Torino, 10125 Torino, ItalyStem Cell Research Institute, University Hospital Gasthuisberg, 3000 Leuven, BelgiumDepartment of Clinical and Biological Sciences, University of Torino, 10125 Torino, ItalySkeletal muscle mass is subject to rapid changes according to growth stimuli inducing both hypertrophy, through increased protein synthesis, and hyperplasia, activating the myogenic program. Muscle wasting, characteristic of several pathological states associated with local or systemic inflammation, has been for long considered to rely on the alteration of myofiber intracellular pathways regulated by both hormones and cytokines, eventually leading to impaired anabolism and increased protein breakdown. However, there are increasing evidences that even alterations of the myogenic/regenerative program play a role in the onset of muscle wasting, even though the precise mechanisms involved are far from being fully elucidated. The comprehension of the links potentially occurring between impaired myogenesis and increased catabolism would allow the definition of effective strategies aimed at counteracting muscle wasting. The first part of this review gives an overview of skeletal muscle intracellular pathways determining fiber size, while the second part considers the cells and the regulatory pathways involved in the myogenic program. In both parts are discussed the evidences supporting the role of inflammation in impairing muscle homeostasis and myogenesis, potentially determining muscle atrophy.http://dx.doi.org/10.1155/2015/805172 |
| spellingShingle | Domiziana Costamagna Paola Costelli Maurilio Sampaolesi Fabio Penna Role of Inflammation in Muscle Homeostasis and Myogenesis Mediators of Inflammation |
| title | Role of Inflammation in Muscle Homeostasis and Myogenesis |
| title_full | Role of Inflammation in Muscle Homeostasis and Myogenesis |
| title_fullStr | Role of Inflammation in Muscle Homeostasis and Myogenesis |
| title_full_unstemmed | Role of Inflammation in Muscle Homeostasis and Myogenesis |
| title_short | Role of Inflammation in Muscle Homeostasis and Myogenesis |
| title_sort | role of inflammation in muscle homeostasis and myogenesis |
| url | http://dx.doi.org/10.1155/2015/805172 |
| work_keys_str_mv | AT domizianacostamagna roleofinflammationinmusclehomeostasisandmyogenesis AT paolacostelli roleofinflammationinmusclehomeostasisandmyogenesis AT mauriliosampaolesi roleofinflammationinmusclehomeostasisandmyogenesis AT fabiopenna roleofinflammationinmusclehomeostasisandmyogenesis |