New perspectives on the glymphatic system and the relationship between glymphatic system and neurodegenerative diseases
Neurodegenerative diseases (ND) are characterized by the accumulation of aggregated proteins. The glymphatic system, through its rapid exchange mechanisms between cerebrospinal fluid (CSF) and interstitial fluid (ISF), facilitates the movement of metabolic substances within the brain, serving functi...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Neurobiology of Disease |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996125000075 |
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| author | Yan-rui Sun Qian-Kun Lv Jun-Yi Liu Fen Wang Chun-Feng Liu |
| author_facet | Yan-rui Sun Qian-Kun Lv Jun-Yi Liu Fen Wang Chun-Feng Liu |
| author_sort | Yan-rui Sun |
| collection | DOAJ |
| description | Neurodegenerative diseases (ND) are characterized by the accumulation of aggregated proteins. The glymphatic system, through its rapid exchange mechanisms between cerebrospinal fluid (CSF) and interstitial fluid (ISF), facilitates the movement of metabolic substances within the brain, serving functions akin to those of the peripheral lymphatic system. This emerging waste clearance mechanism offers a novel perspective on the removal of pathological substances in ND. This article elucidates recent discoveries regarding the glymphatic system and updates relevant concepts within its model. It discusses the potential roles of the glymphatic system in ND, including Alzheimer's disease (AD), Parkinson's disease (PD), and multiple system atrophy (MSA), and proposes the glymphatic system as a novel therapeutic target for these conditions. |
| format | Article |
| id | doaj-art-922d061a429044c988abc846c1f4854b |
| institution | Kabale University |
| issn | 1095-953X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Disease |
| spelling | doaj-art-922d061a429044c988abc846c1f4854b2025-01-24T04:44:41ZengElsevierNeurobiology of Disease1095-953X2025-02-01205106791New perspectives on the glymphatic system and the relationship between glymphatic system and neurodegenerative diseasesYan-rui Sun0Qian-Kun Lv1Jun-Yi Liu2Fen Wang3Chun-Feng Liu4Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou 215123, ChinaDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou 215123, ChinaDepartment of Neurology, Dushu Lake hospital affilicated to Soochow University, Suzhou, ChinaDepartment of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou 215123, China; Corresponding authors at: Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China; Jiangsu Key Laboratory of Neuropsychiatric Diseases and Institute of Neuroscience, Soochow University, Suzhou 215123, China; Corresponding authors at: Department of Neurology and Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China.Neurodegenerative diseases (ND) are characterized by the accumulation of aggregated proteins. The glymphatic system, through its rapid exchange mechanisms between cerebrospinal fluid (CSF) and interstitial fluid (ISF), facilitates the movement of metabolic substances within the brain, serving functions akin to those of the peripheral lymphatic system. This emerging waste clearance mechanism offers a novel perspective on the removal of pathological substances in ND. This article elucidates recent discoveries regarding the glymphatic system and updates relevant concepts within its model. It discusses the potential roles of the glymphatic system in ND, including Alzheimer's disease (AD), Parkinson's disease (PD), and multiple system atrophy (MSA), and proposes the glymphatic system as a novel therapeutic target for these conditions.http://www.sciencedirect.com/science/article/pii/S0969996125000075Glymphatic systemNeurodegenerative diseasesCerebrospinal fluidPerivascular spaces |
| spellingShingle | Yan-rui Sun Qian-Kun Lv Jun-Yi Liu Fen Wang Chun-Feng Liu New perspectives on the glymphatic system and the relationship between glymphatic system and neurodegenerative diseases Neurobiology of Disease Glymphatic system Neurodegenerative diseases Cerebrospinal fluid Perivascular spaces |
| title | New perspectives on the glymphatic system and the relationship between glymphatic system and neurodegenerative diseases |
| title_full | New perspectives on the glymphatic system and the relationship between glymphatic system and neurodegenerative diseases |
| title_fullStr | New perspectives on the glymphatic system and the relationship between glymphatic system and neurodegenerative diseases |
| title_full_unstemmed | New perspectives on the glymphatic system and the relationship between glymphatic system and neurodegenerative diseases |
| title_short | New perspectives on the glymphatic system and the relationship between glymphatic system and neurodegenerative diseases |
| title_sort | new perspectives on the glymphatic system and the relationship between glymphatic system and neurodegenerative diseases |
| topic | Glymphatic system Neurodegenerative diseases Cerebrospinal fluid Perivascular spaces |
| url | http://www.sciencedirect.com/science/article/pii/S0969996125000075 |
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