Marine Diterpenoids as Potential Anti-Inflammatory Agents
The inflammatory response is a highly regulated process, and its dysregulation can lead to the establishment of chronic inflammation and, in some cases, to death. Inflammation is the cause of several diseases, including rheumatoid arthritis, inflammatory bowel diseases, multiple sclerosis, and asthm...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/263543 |
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| _version_ | 1832550227067797504 |
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| author | Yisett González Daniel Torres-Mendoza Gillian E. Jones Patricia L. Fernandez |
| author_facet | Yisett González Daniel Torres-Mendoza Gillian E. Jones Patricia L. Fernandez |
| author_sort | Yisett González |
| collection | DOAJ |
| description | The inflammatory response is a highly regulated process, and its dysregulation can lead to the establishment of chronic inflammation and, in some cases, to death. Inflammation is the cause of several diseases, including rheumatoid arthritis, inflammatory bowel diseases, multiple sclerosis, and asthma. The search for agents inhibiting inflammation is a great challenge as the inflammatory response plays an important role in the defense of the host to infections. Marine invertebrates are exceptional sources of new natural products, and among those diterpenoids secondary metabolites exhibit notable anti-inflammatory properties. Novel anti-inflammatory diterpenoids, exclusively produced by marine organisms, have been identified and synthetic molecules based on those structures have been obtained. The anti-inflammatory activity of marine diterpenoids has been attributed to the inhibition of Nuclear Factor-κB activation and to the modulation of arachidonic acid metabolism. However, more research is necessary to describe the mechanisms of action of these secondary metabolites. This review is a compilation of marine diterpenoids, mainly isolated from corals, which have been described as potential anti-inflammatory molecules. |
| format | Article |
| id | doaj-art-9224e2c092b749bc908082b5d8fc3b58 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-9224e2c092b749bc908082b5d8fc3b582025-02-03T06:07:25ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/263543263543Marine Diterpenoids as Potential Anti-Inflammatory AgentsYisett González0Daniel Torres-Mendoza1Gillian E. Jones2Patricia L. Fernandez3Centro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Ciudad de Panamá, PanamaDepartment of Biotechnology, Acharya Nagarjuna University, Guntur 522510, IndiaCentro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Ciudad de Panamá, PanamaCentro de Biología Celular y Molecular de Enfermedades, Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP), Ciudad de Panamá, PanamaThe inflammatory response is a highly regulated process, and its dysregulation can lead to the establishment of chronic inflammation and, in some cases, to death. Inflammation is the cause of several diseases, including rheumatoid arthritis, inflammatory bowel diseases, multiple sclerosis, and asthma. The search for agents inhibiting inflammation is a great challenge as the inflammatory response plays an important role in the defense of the host to infections. Marine invertebrates are exceptional sources of new natural products, and among those diterpenoids secondary metabolites exhibit notable anti-inflammatory properties. Novel anti-inflammatory diterpenoids, exclusively produced by marine organisms, have been identified and synthetic molecules based on those structures have been obtained. The anti-inflammatory activity of marine diterpenoids has been attributed to the inhibition of Nuclear Factor-κB activation and to the modulation of arachidonic acid metabolism. However, more research is necessary to describe the mechanisms of action of these secondary metabolites. This review is a compilation of marine diterpenoids, mainly isolated from corals, which have been described as potential anti-inflammatory molecules.http://dx.doi.org/10.1155/2015/263543 |
| spellingShingle | Yisett González Daniel Torres-Mendoza Gillian E. Jones Patricia L. Fernandez Marine Diterpenoids as Potential Anti-Inflammatory Agents Mediators of Inflammation |
| title | Marine Diterpenoids as Potential Anti-Inflammatory Agents |
| title_full | Marine Diterpenoids as Potential Anti-Inflammatory Agents |
| title_fullStr | Marine Diterpenoids as Potential Anti-Inflammatory Agents |
| title_full_unstemmed | Marine Diterpenoids as Potential Anti-Inflammatory Agents |
| title_short | Marine Diterpenoids as Potential Anti-Inflammatory Agents |
| title_sort | marine diterpenoids as potential anti inflammatory agents |
| url | http://dx.doi.org/10.1155/2015/263543 |
| work_keys_str_mv | AT yisettgonzalez marinediterpenoidsaspotentialantiinflammatoryagents AT danieltorresmendoza marinediterpenoidsaspotentialantiinflammatoryagents AT gillianejones marinediterpenoidsaspotentialantiinflammatoryagents AT patricialfernandez marinediterpenoidsaspotentialantiinflammatoryagents |