Molecular epidemiological investigations of human parvovirus B19 among blood donors in Lanzhou
[Objective] To investigate the molecular prevalence and genotype of human parvovirus B19(B19) among blood donors in Lanzhou, and provide data support for monitoring the positive rate of B19 DNA in local blood donors. [Methods] A total of 7 644 blood donor samples collected from January to September...
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| Format: | Article |
| Language: | zho |
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Institute of Blood Transfusion of Chinese Academy of Medical Sciences
2025-01-01
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| Series: | Zhongguo shuxue zazhi |
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| Online Access: | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.01.011&lang=en |
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| _version_ | 1832585141148450816 |
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| author | WU Kangle YANG Shulong FENG Weiping WANG Weirong PAN Deng |
| author_facet | WU Kangle YANG Shulong FENG Weiping WANG Weirong PAN Deng |
| author_sort | WU Kangle |
| collection | DOAJ |
| description | [Objective] To investigate the molecular prevalence and genotype of human parvovirus B19(B19) among blood donors in Lanzhou, and provide data support for monitoring the positive rate of B19 DNA in local blood donors. [Methods] A total of 7 644 blood donor samples collected from January to September 2022 were randomly screened using real-time fluorescent PCR, resulting in 23 samples testing positive for B19 DNA. The characteristics of the B19 DNA reactive donors including gender, age, blood donation recruitment and promotion mode, and donation frequency were analyzed using SPSS 22.0. Additionally, the VP1 gene fragment of B19 DNA reactive samples was sequenced and an evolutionary tree was constructed by the N-J method. [Results] The results showed that the positive rate of B19 DNA in Lanzhou was 0.30%, and the positive population mainly consisted of female individuals aged 18-30 years old who were first-time blood donors; furthermore, genotype 1a was identified as predominant. [Conclusion] The positive rate of B19 DNA is low among blood donors in Lanzhou, with genotype 1a being predominant. It is recommended to periodically monitor the B19 prevalence in blood donors and enhance prevention and control measures, thus improving blood quality and safety. |
| format | Article |
| id | doaj-art-9217c6c3d35f4d04a3b76306a4be2d2a |
| institution | Kabale University |
| issn | 1004-549X |
| language | zho |
| publishDate | 2025-01-01 |
| publisher | Institute of Blood Transfusion of Chinese Academy of Medical Sciences |
| record_format | Article |
| series | Zhongguo shuxue zazhi |
| spelling | doaj-art-9217c6c3d35f4d04a3b76306a4be2d2a2025-01-27T01:46:11ZzhoInstitute of Blood Transfusion of Chinese Academy of Medical SciencesZhongguo shuxue zazhi1004-549X2025-01-01381687210.13303/j.cjbt.issn.1004-549x.2025.01.0111004-549X(2025)1-0068-05Molecular epidemiological investigations of human parvovirus B19 among blood donors in LanzhouWU Kangle0YANG Shulong1FENG Weiping2WANG Weirong3PAN Deng4Gansu Red Cross Blood Center, Lanzhou 730046, ChinaGansu Red Cross Blood Center, Lanzhou 730046, ChinaGansu Red Cross Blood Center, Lanzhou 730046, ChinaGansu Red Cross Blood Center, Lanzhou 730046, ChinaGansu Red Cross Blood Center, Lanzhou 730046, China[Objective] To investigate the molecular prevalence and genotype of human parvovirus B19(B19) among blood donors in Lanzhou, and provide data support for monitoring the positive rate of B19 DNA in local blood donors. [Methods] A total of 7 644 blood donor samples collected from January to September 2022 were randomly screened using real-time fluorescent PCR, resulting in 23 samples testing positive for B19 DNA. The characteristics of the B19 DNA reactive donors including gender, age, blood donation recruitment and promotion mode, and donation frequency were analyzed using SPSS 22.0. Additionally, the VP1 gene fragment of B19 DNA reactive samples was sequenced and an evolutionary tree was constructed by the N-J method. [Results] The results showed that the positive rate of B19 DNA in Lanzhou was 0.30%, and the positive population mainly consisted of female individuals aged 18-30 years old who were first-time blood donors; furthermore, genotype 1a was identified as predominant. [Conclusion] The positive rate of B19 DNA is low among blood donors in Lanzhou, with genotype 1a being predominant. It is recommended to periodically monitor the B19 prevalence in blood donors and enhance prevention and control measures, thus improving blood quality and safety.https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.01.011&lang=enhuman parvovirus b19blood donorsgenotype |
| spellingShingle | WU Kangle YANG Shulong FENG Weiping WANG Weirong PAN Deng Molecular epidemiological investigations of human parvovirus B19 among blood donors in Lanzhou Zhongguo shuxue zazhi human parvovirus b19 blood donors genotype |
| title | Molecular epidemiological investigations of human parvovirus B19 among blood donors in Lanzhou |
| title_full | Molecular epidemiological investigations of human parvovirus B19 among blood donors in Lanzhou |
| title_fullStr | Molecular epidemiological investigations of human parvovirus B19 among blood donors in Lanzhou |
| title_full_unstemmed | Molecular epidemiological investigations of human parvovirus B19 among blood donors in Lanzhou |
| title_short | Molecular epidemiological investigations of human parvovirus B19 among blood donors in Lanzhou |
| title_sort | molecular epidemiological investigations of human parvovirus b19 among blood donors in lanzhou |
| topic | human parvovirus b19 blood donors genotype |
| url | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.01.011&lang=en |
| work_keys_str_mv | AT wukangle molecularepidemiologicalinvestigationsofhumanparvovirusb19amongblooddonorsinlanzhou AT yangshulong molecularepidemiologicalinvestigationsofhumanparvovirusb19amongblooddonorsinlanzhou AT fengweiping molecularepidemiologicalinvestigationsofhumanparvovirusb19amongblooddonorsinlanzhou AT wangweirong molecularepidemiologicalinvestigationsofhumanparvovirusb19amongblooddonorsinlanzhou AT pandeng molecularepidemiologicalinvestigationsofhumanparvovirusb19amongblooddonorsinlanzhou |