Inflammatory-Related Clinical and Metabolic Outcomes in COVID-19 Patients
Background. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) infection elicits inflammatory manifestations that relate with a “cytokine storm.” Objective. The aim of this research was to assess the role of circulating interleukin 6 (IL-6) levels and other inflammatory markers in patients...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2020/2914275 |
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| author | Maria Martinez-Urbistondo Alberto Mora-Vargas Esther Expósito-Palomo Raquel Castejón M. Jesús Citores Silvia Rosado Carmen de Mendoza Isolina Baños Ana Fernández-Cruz Lidia Daimiel Rodrigo San-Cristóbal Juan Antonio Vargas J. Alfredo Martinez |
| author_facet | Maria Martinez-Urbistondo Alberto Mora-Vargas Esther Expósito-Palomo Raquel Castejón M. Jesús Citores Silvia Rosado Carmen de Mendoza Isolina Baños Ana Fernández-Cruz Lidia Daimiel Rodrigo San-Cristóbal Juan Antonio Vargas J. Alfredo Martinez |
| author_sort | Maria Martinez-Urbistondo |
| collection | DOAJ |
| description | Background. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) infection elicits inflammatory manifestations that relate with a “cytokine storm.” Objective. The aim of this research was to assess the role of circulating interleukin 6 (IL-6) levels and other inflammatory markers in patients with coronavirus disease 2019 (COVID-19) on metabolic functions and accompanying clinical complications. Patients and Methods. A total of 165 patients diagnosed with COVID-19 pneumonia were examined for medical features and inflammatory markers such as blood IL-6, CRP, ferritin, LDH, neutrophil/lymphocyte index (NLI), D-Dimer, and Red Cell Distribution Width (RDW). Regression analyses concerning electronically collected medical data were adjusted by appropriate factors and confounding variables. Results. Plasma IL-6 determinations evidenced a consistent association with hospital stay days, Intensive Care Unit (ICU) admission, and mortality rates. Similar trends were found for other proinflammatory variables, where ferritin and NLI showed a remarkable value as surrogates. Hyperglycaemia and the Charlson Comorbidity Index Score were positively associated with the inflammatory response induced by the SARS-COV-2 infection. An unhealthy lifestyle such as smoking and alcoholic drinks consumption as well as excessive body adiposity influenced inflammatory-related outcomes in the screened patients. Conclusion. IL-6 together with other inflammatory biomarkers accompanied poor clinical and metabolic outcomes in COVID-19-infected patients. IL-6 may result in a suitable proxy to individually categorise patients in order to manage this infectious pandemic. |
| format | Article |
| id | doaj-art-920d91dafbae4520811943f3ff9ffb71 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-920d91dafbae4520811943f3ff9ffb712025-02-03T01:28:24ZengWileyMediators of Inflammation0962-93511466-18612020-01-01202010.1155/2020/29142752914275Inflammatory-Related Clinical and Metabolic Outcomes in COVID-19 PatientsMaria Martinez-Urbistondo0Alberto Mora-Vargas1Esther Expósito-Palomo2Raquel Castejón3M. Jesús Citores4Silvia Rosado5Carmen de Mendoza6Isolina Baños7Ana Fernández-Cruz8Lidia Daimiel9Rodrigo San-Cristóbal10Juan Antonio Vargas11J. Alfredo Martinez12Internal Medicine Department, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, SpainInternal Medicine Department, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, SpainInternal Medicine Department, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, SpainInternal Medicine Department, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, SpainInternal Medicine Department, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, SpainInternal Medicine Department, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, SpainInternal Medicine Department, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, SpainInternal Medicine Department, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, SpainInternal Medicine Department, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, SpainPrecision Nutrition Program. IMDEAFood. UAM-CSIC. Madrid, SpainPrecision Nutrition Program. IMDEAFood. UAM-CSIC. Madrid, SpainInternal Medicine Department, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, SpainPrecision Nutrition Program. IMDEAFood. UAM-CSIC. Madrid, SpainBackground. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) infection elicits inflammatory manifestations that relate with a “cytokine storm.” Objective. The aim of this research was to assess the role of circulating interleukin 6 (IL-6) levels and other inflammatory markers in patients with coronavirus disease 2019 (COVID-19) on metabolic functions and accompanying clinical complications. Patients and Methods. A total of 165 patients diagnosed with COVID-19 pneumonia were examined for medical features and inflammatory markers such as blood IL-6, CRP, ferritin, LDH, neutrophil/lymphocyte index (NLI), D-Dimer, and Red Cell Distribution Width (RDW). Regression analyses concerning electronically collected medical data were adjusted by appropriate factors and confounding variables. Results. Plasma IL-6 determinations evidenced a consistent association with hospital stay days, Intensive Care Unit (ICU) admission, and mortality rates. Similar trends were found for other proinflammatory variables, where ferritin and NLI showed a remarkable value as surrogates. Hyperglycaemia and the Charlson Comorbidity Index Score were positively associated with the inflammatory response induced by the SARS-COV-2 infection. An unhealthy lifestyle such as smoking and alcoholic drinks consumption as well as excessive body adiposity influenced inflammatory-related outcomes in the screened patients. Conclusion. IL-6 together with other inflammatory biomarkers accompanied poor clinical and metabolic outcomes in COVID-19-infected patients. IL-6 may result in a suitable proxy to individually categorise patients in order to manage this infectious pandemic.http://dx.doi.org/10.1155/2020/2914275 |
| spellingShingle | Maria Martinez-Urbistondo Alberto Mora-Vargas Esther Expósito-Palomo Raquel Castejón M. Jesús Citores Silvia Rosado Carmen de Mendoza Isolina Baños Ana Fernández-Cruz Lidia Daimiel Rodrigo San-Cristóbal Juan Antonio Vargas J. Alfredo Martinez Inflammatory-Related Clinical and Metabolic Outcomes in COVID-19 Patients Mediators of Inflammation |
| title | Inflammatory-Related Clinical and Metabolic Outcomes in COVID-19 Patients |
| title_full | Inflammatory-Related Clinical and Metabolic Outcomes in COVID-19 Patients |
| title_fullStr | Inflammatory-Related Clinical and Metabolic Outcomes in COVID-19 Patients |
| title_full_unstemmed | Inflammatory-Related Clinical and Metabolic Outcomes in COVID-19 Patients |
| title_short | Inflammatory-Related Clinical and Metabolic Outcomes in COVID-19 Patients |
| title_sort | inflammatory related clinical and metabolic outcomes in covid 19 patients |
| url | http://dx.doi.org/10.1155/2020/2914275 |
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