Mapping transcriptomic profiles of seminal vesiculitis and experimental verification
Objective: Seminal vesiculitis is a prevalent infectious disease in the genitourinary system, but its intrinsic pathogenesis and molecular features remain unclear. Methods: In this study, we utilized a next-generation sequencing technology to demonstrate transcriptomic landscapes of clinical specime...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Asian Journal of Urology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221438822400122X |
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| author | Chenkui Miao Shaobo Zhang Jiajin Wu Meiling Bao Zengjun Wang Bianjiang Liu |
| author_facet | Chenkui Miao Shaobo Zhang Jiajin Wu Meiling Bao Zengjun Wang Bianjiang Liu |
| author_sort | Chenkui Miao |
| collection | DOAJ |
| description | Objective: Seminal vesiculitis is a prevalent infectious disease in the genitourinary system, but its intrinsic pathogenesis and molecular features remain unclear. Methods: In this study, we utilized a next-generation sequencing technology to demonstrate transcriptomic landscapes of clinical specimens from seminal vesiculitis patients. We identified enriched Go Ontology terms, pathway maps, processes, toxicity, and metabolic networks of seminal vesiculitis. Results: Glutathione S-transferase activity is highly enriched, indicating its essential role in the disease's development. Furthermore, we established inflammation models of the seminal vesicle and verified the crucial function of glutathione S-transferase activity in these models. Conclusion: Glutathione S-transferase serves an essential role in seminal vesiculitis patients. Our results shall provide a robust platform for further intensive studies of seminal vesiculitis. |
| format | Article |
| id | doaj-art-91f8c2b23708490bafec3d380293a435 |
| institution | Kabale University |
| issn | 2214-3882 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Urology |
| spelling | doaj-art-91f8c2b23708490bafec3d380293a4352025-01-30T05:14:18ZengElsevierAsian Journal of Urology2214-38822025-01-01121106115Mapping transcriptomic profiles of seminal vesiculitis and experimental verificationChenkui Miao0Shaobo Zhang1Jiajin Wu2Meiling Bao3Zengjun Wang4Bianjiang Liu5Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Pathology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China; Corresponding author.Objective: Seminal vesiculitis is a prevalent infectious disease in the genitourinary system, but its intrinsic pathogenesis and molecular features remain unclear. Methods: In this study, we utilized a next-generation sequencing technology to demonstrate transcriptomic landscapes of clinical specimens from seminal vesiculitis patients. We identified enriched Go Ontology terms, pathway maps, processes, toxicity, and metabolic networks of seminal vesiculitis. Results: Glutathione S-transferase activity is highly enriched, indicating its essential role in the disease's development. Furthermore, we established inflammation models of the seminal vesicle and verified the crucial function of glutathione S-transferase activity in these models. Conclusion: Glutathione S-transferase serves an essential role in seminal vesiculitis patients. Our results shall provide a robust platform for further intensive studies of seminal vesiculitis.http://www.sciencedirect.com/science/article/pii/S221438822400122XSeminal vesicleInflammationTranscriptomeGlutathione S-transferase |
| spellingShingle | Chenkui Miao Shaobo Zhang Jiajin Wu Meiling Bao Zengjun Wang Bianjiang Liu Mapping transcriptomic profiles of seminal vesiculitis and experimental verification Asian Journal of Urology Seminal vesicle Inflammation Transcriptome Glutathione S-transferase |
| title | Mapping transcriptomic profiles of seminal vesiculitis and experimental verification |
| title_full | Mapping transcriptomic profiles of seminal vesiculitis and experimental verification |
| title_fullStr | Mapping transcriptomic profiles of seminal vesiculitis and experimental verification |
| title_full_unstemmed | Mapping transcriptomic profiles of seminal vesiculitis and experimental verification |
| title_short | Mapping transcriptomic profiles of seminal vesiculitis and experimental verification |
| title_sort | mapping transcriptomic profiles of seminal vesiculitis and experimental verification |
| topic | Seminal vesicle Inflammation Transcriptome Glutathione S-transferase |
| url | http://www.sciencedirect.com/science/article/pii/S221438822400122X |
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