Associated Factors with Biochemical Hypoglycemia during an Oral Glucose Tolerance Test in a Chinese Population
Aim. To find the association between biochemical hypoglycemia on a 2-hour screening oral glucose tolerance test (OGTT) and insulin resistance. Method. Subjects of this study were sampled from the China National Diabetes and Metabolic Disorders Study that was conducted during 2007 and 2008. Blood sam...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2017/3212814 |
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| _version_ | 1832556202571071488 |
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| author | Xiaoling Cai Xueyao Han Xianghai Zhou Lingli Zhou Simin Zhang Linong Ji |
| author_facet | Xiaoling Cai Xueyao Han Xianghai Zhou Lingli Zhou Simin Zhang Linong Ji |
| author_sort | Xiaoling Cai |
| collection | DOAJ |
| description | Aim. To find the association between biochemical hypoglycemia on a 2-hour screening oral glucose tolerance test (OGTT) and insulin resistance. Method. Subjects of this study were sampled from the China National Diabetes and Metabolic Disorders Study that was conducted during 2007 and 2008. Blood samples were drawn at 0, 30, and 120 minutes after the glucose load. Biochemical hypoglycemia was defined as 2-hour glucose < 3.0 mmol/l. Results. In total, 26,606 participants were included, and 141 participants were diagnosed with biochemical hypoglycemia on a 2-hour OGTT. Compared to participants with normal glucose tolerance (NGT), participants with biochemical hypoglycemia presented with a younger age, lower BMI, lower levels of fasting glucose, and lower levels of 30-minute and 2-hour OGTT glucose. In terms of insulin resistance, participants with biochemical hypoglycemia showed higher levels of Matsuda ISI. In terms of β-cell function, participants with biochemical hypoglycemia showed higher levels of Stumvoll early and late indexes. A multivariate regression analysis indicated that higher levels of Matsuda ISI and higher levels of Stumvoll early and late indexes were associated with biochemical hypoglycemia independently. Conclusion. This study indicated that biochemical hypoglycemia might be associated with lower levels of insulin resistance but higher levels of β-cell function in a Chinese population. |
| format | Article |
| id | doaj-art-91e068f8749943b0a327557c42db2b21 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-91e068f8749943b0a327557c42db2b212025-02-03T05:46:09ZengWileyJournal of Diabetes Research2314-67452314-67532017-01-01201710.1155/2017/32128143212814Associated Factors with Biochemical Hypoglycemia during an Oral Glucose Tolerance Test in a Chinese PopulationXiaoling Cai0Xueyao Han1Xianghai Zhou2Lingli Zhou3Simin Zhang4Linong Ji5Endocrine and Metabolism Department, Peking University People’s Hospital, Beijing 100044, ChinaEndocrine and Metabolism Department, Peking University People’s Hospital, Beijing 100044, ChinaEndocrine and Metabolism Department, Peking University People’s Hospital, Beijing 100044, ChinaEndocrine and Metabolism Department, Peking University People’s Hospital, Beijing 100044, ChinaEndocrine and Metabolism Department, Peking University People’s Hospital, Beijing 100044, ChinaEndocrine and Metabolism Department, Peking University People’s Hospital, Beijing 100044, ChinaAim. To find the association between biochemical hypoglycemia on a 2-hour screening oral glucose tolerance test (OGTT) and insulin resistance. Method. Subjects of this study were sampled from the China National Diabetes and Metabolic Disorders Study that was conducted during 2007 and 2008. Blood samples were drawn at 0, 30, and 120 minutes after the glucose load. Biochemical hypoglycemia was defined as 2-hour glucose < 3.0 mmol/l. Results. In total, 26,606 participants were included, and 141 participants were diagnosed with biochemical hypoglycemia on a 2-hour OGTT. Compared to participants with normal glucose tolerance (NGT), participants with biochemical hypoglycemia presented with a younger age, lower BMI, lower levels of fasting glucose, and lower levels of 30-minute and 2-hour OGTT glucose. In terms of insulin resistance, participants with biochemical hypoglycemia showed higher levels of Matsuda ISI. In terms of β-cell function, participants with biochemical hypoglycemia showed higher levels of Stumvoll early and late indexes. A multivariate regression analysis indicated that higher levels of Matsuda ISI and higher levels of Stumvoll early and late indexes were associated with biochemical hypoglycemia independently. Conclusion. This study indicated that biochemical hypoglycemia might be associated with lower levels of insulin resistance but higher levels of β-cell function in a Chinese population.http://dx.doi.org/10.1155/2017/3212814 |
| spellingShingle | Xiaoling Cai Xueyao Han Xianghai Zhou Lingli Zhou Simin Zhang Linong Ji Associated Factors with Biochemical Hypoglycemia during an Oral Glucose Tolerance Test in a Chinese Population Journal of Diabetes Research |
| title | Associated Factors with Biochemical Hypoglycemia during an Oral Glucose Tolerance Test in a Chinese Population |
| title_full | Associated Factors with Biochemical Hypoglycemia during an Oral Glucose Tolerance Test in a Chinese Population |
| title_fullStr | Associated Factors with Biochemical Hypoglycemia during an Oral Glucose Tolerance Test in a Chinese Population |
| title_full_unstemmed | Associated Factors with Biochemical Hypoglycemia during an Oral Glucose Tolerance Test in a Chinese Population |
| title_short | Associated Factors with Biochemical Hypoglycemia during an Oral Glucose Tolerance Test in a Chinese Population |
| title_sort | associated factors with biochemical hypoglycemia during an oral glucose tolerance test in a chinese population |
| url | http://dx.doi.org/10.1155/2017/3212814 |
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