Non-linear relationship between urinary creatinine and diabetic kidney disease: implications for clinical practice
Abstract Objective This study aims to investigate the relationship between urinary creatinine (UCr) and the risk and severity of Diabetic Kidney Disease (DKD) in patients with Type 2 Diabetes Mellitus (T2DM). The goal is to establish UCr as a potential biomarker for early DKD detection and severity...
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| Language: | English |
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BMC
2025-01-01
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| Series: | BMC Nephrology |
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| Online Access: | https://doi.org/10.1186/s12882-025-03971-1 |
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| author | Huihong Cao Li Song Xiaojun Wang Haochen Guan |
| author_facet | Huihong Cao Li Song Xiaojun Wang Haochen Guan |
| author_sort | Huihong Cao |
| collection | DOAJ |
| description | Abstract Objective This study aims to investigate the relationship between urinary creatinine (UCr) and the risk and severity of Diabetic Kidney Disease (DKD) in patients with Type 2 Diabetes Mellitus (T2DM). The goal is to establish UCr as a potential biomarker for early DKD detection and severity assessment. Methods A retrospective cross-sectional analysis was conducted using medical records of T2DM patients. Patients were classified into groups with and without DKD, and relevant clinical data, including demographic, blood, and urine parameters, were collected. Logistic regression and receiver operating characteristic (ROC) curve analysis evaluated the association between UCr levels and DKD. Curve fitting and threshold effect model were used to further evaluate the relationship between UCr and the incidence and severity of DKD. Results A total of 302 T2DM patients were analyzed, with 137 diagnosed with DKD. Significant differences in clinical parameters were observed between the DKD and non-DKD groups, particularly in UCr, urine albumin levels, and eGFR. UCr levels demonstrated a strong association with DKD. Moreover, a non-linear relationship was identified, with specific inflection points indicating different correlation patterns of UCr with DKD occurrence and progression. Conclusion The findings of this study highlight the potential of UCr as a valuable biomarker for early detection and assessment of DKD in T2DM patients. Incorporating UCr measurements into routine clinical practice could enhance early identification of patients at risk for kidney complications, leading to timely intervention and improved patient outcomes. |
| format | Article |
| id | doaj-art-91d55436109e4315bed5c47fd12df7ba |
| institution | Kabale University |
| issn | 1471-2369 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj-art-91d55436109e4315bed5c47fd12df7ba2025-01-26T12:19:36ZengBMCBMC Nephrology1471-23692025-01-012611810.1186/s12882-025-03971-1Non-linear relationship between urinary creatinine and diabetic kidney disease: implications for clinical practiceHuihong Cao0Li Song1Xiaojun Wang2Haochen Guan3Department of Endocrinology of Shanghai Minhang Hospital of Integrated Traditional Chinese and Western MedicineDepartment of Endocrinology of Shanghai Minhang Hospital of Integrated Traditional Chinese and Western MedicineShanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital Affiliated to Fudan UniversityDepartment of Nephrology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of ChinaAbstract Objective This study aims to investigate the relationship between urinary creatinine (UCr) and the risk and severity of Diabetic Kidney Disease (DKD) in patients with Type 2 Diabetes Mellitus (T2DM). The goal is to establish UCr as a potential biomarker for early DKD detection and severity assessment. Methods A retrospective cross-sectional analysis was conducted using medical records of T2DM patients. Patients were classified into groups with and without DKD, and relevant clinical data, including demographic, blood, and urine parameters, were collected. Logistic regression and receiver operating characteristic (ROC) curve analysis evaluated the association between UCr levels and DKD. Curve fitting and threshold effect model were used to further evaluate the relationship between UCr and the incidence and severity of DKD. Results A total of 302 T2DM patients were analyzed, with 137 diagnosed with DKD. Significant differences in clinical parameters were observed between the DKD and non-DKD groups, particularly in UCr, urine albumin levels, and eGFR. UCr levels demonstrated a strong association with DKD. Moreover, a non-linear relationship was identified, with specific inflection points indicating different correlation patterns of UCr with DKD occurrence and progression. Conclusion The findings of this study highlight the potential of UCr as a valuable biomarker for early detection and assessment of DKD in T2DM patients. Incorporating UCr measurements into routine clinical practice could enhance early identification of patients at risk for kidney complications, leading to timely intervention and improved patient outcomes.https://doi.org/10.1186/s12882-025-03971-1Diabetic kidney diseaseType 2 diabetes MellitusUrinary creatinineBiomarkerEarly detectionRenal function |
| spellingShingle | Huihong Cao Li Song Xiaojun Wang Haochen Guan Non-linear relationship between urinary creatinine and diabetic kidney disease: implications for clinical practice BMC Nephrology Diabetic kidney disease Type 2 diabetes Mellitus Urinary creatinine Biomarker Early detection Renal function |
| title | Non-linear relationship between urinary creatinine and diabetic kidney disease: implications for clinical practice |
| title_full | Non-linear relationship between urinary creatinine and diabetic kidney disease: implications for clinical practice |
| title_fullStr | Non-linear relationship between urinary creatinine and diabetic kidney disease: implications for clinical practice |
| title_full_unstemmed | Non-linear relationship between urinary creatinine and diabetic kidney disease: implications for clinical practice |
| title_short | Non-linear relationship between urinary creatinine and diabetic kidney disease: implications for clinical practice |
| title_sort | non linear relationship between urinary creatinine and diabetic kidney disease implications for clinical practice |
| topic | Diabetic kidney disease Type 2 diabetes Mellitus Urinary creatinine Biomarker Early detection Renal function |
| url | https://doi.org/10.1186/s12882-025-03971-1 |
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