Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions
Ebola virus is responsible for causing severe hemorrhagic fevers, with case fatality rates of up to 90%. Currently, no antiviral or vaccine is licensed against Ebola virus. A phosphatidylserine-targeting antibody (PGN401, bavituximab) has previously been shown to have broad-spectrum antiviral activi...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/347903 |
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| author | S. D. Dowall V. A. Graham K. Corbin-Lickfett C. Empig K. Schlunegger C. B. Bruce L. Easterbrook R. Hewson |
| author_facet | S. D. Dowall V. A. Graham K. Corbin-Lickfett C. Empig K. Schlunegger C. B. Bruce L. Easterbrook R. Hewson |
| author_sort | S. D. Dowall |
| collection | DOAJ |
| description | Ebola virus is responsible for causing severe hemorrhagic fevers, with case fatality rates of up to 90%. Currently, no antiviral or vaccine is licensed against Ebola virus. A phosphatidylserine-targeting antibody (PGN401, bavituximab) has previously been shown to have broad-spectrum antiviral activity. Here, we demonstrate that PGN401 specifically binds to Ebola virus and recognizes infected cells. Our study provides the first evidence of phosphatidylserine-targeting antibody reactivity against Ebola virus. |
| format | Article |
| id | doaj-art-91c5ea9b8953419998449a915f3d3920 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-91c5ea9b8953419998449a915f3d39202025-02-03T05:52:07ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/347903347903Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified VirionsS. D. Dowall0V. A. Graham1K. Corbin-Lickfett2C. Empig3K. Schlunegger4C. B. Bruce5L. Easterbrook6R. Hewson7Public Health England, Porton Down, Wiltshire, Salisbury SP4 0JG, UKPublic Health England, Porton Down, Wiltshire, Salisbury SP4 0JG, UKPeregrine Pharmaceuticals, Inc., Tustin, CA 92780, USAPeregrine Pharmaceuticals, Inc., Tustin, CA 92780, USAPeregrine Pharmaceuticals, Inc., Tustin, CA 92780, USAPublic Health England, Porton Down, Wiltshire, Salisbury SP4 0JG, UKPublic Health England, Porton Down, Wiltshire, Salisbury SP4 0JG, UKPublic Health England, Porton Down, Wiltshire, Salisbury SP4 0JG, UKEbola virus is responsible for causing severe hemorrhagic fevers, with case fatality rates of up to 90%. Currently, no antiviral or vaccine is licensed against Ebola virus. A phosphatidylserine-targeting antibody (PGN401, bavituximab) has previously been shown to have broad-spectrum antiviral activity. Here, we demonstrate that PGN401 specifically binds to Ebola virus and recognizes infected cells. Our study provides the first evidence of phosphatidylserine-targeting antibody reactivity against Ebola virus.http://dx.doi.org/10.1155/2015/347903 |
| spellingShingle | S. D. Dowall V. A. Graham K. Corbin-Lickfett C. Empig K. Schlunegger C. B. Bruce L. Easterbrook R. Hewson Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions Journal of Immunology Research |
| title | Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions |
| title_full | Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions |
| title_fullStr | Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions |
| title_full_unstemmed | Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions |
| title_short | Effective Binding of a Phosphatidylserine-Targeting Antibody to Ebola Virus Infected Cells and Purified Virions |
| title_sort | effective binding of a phosphatidylserine targeting antibody to ebola virus infected cells and purified virions |
| url | http://dx.doi.org/10.1155/2015/347903 |
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