Proteomics-based aging clocks in midlife or late-life and their associated risk of dementia

Proteomics-based aging clocks in midlife or late-life and their associated risk of dementia

Abstract Background: Biological age can be quantified by composite proteomic scores, called proteomics-based aging clocks (PACs). We investigated whether a discrepancy between chronological and biological age in midlife and late-life is associated with cognition and dementia risk. Methods: We used t...

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Main Authors: Sanaz Sedaghat, Saeun Park, Rob F. Walker, Shuo Wang, Jialing Liu, Timothy M. Hughes, Behnam Sabayan, Weihong Tang, Josef Coresh, James S. Pankow, Keenan A. Walker, Ramon Casanova, Ruth Dubin, Rajat Deo, Jerome I. Rotter, Alexis C. Wood, Peter Ganz, Pamela L. Lutsey, Weihua Guan, Anna Prizment
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-025-01096-y
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