Leukotriene Receptors: Crucial Components in Vascular Inflammation
The accumulation of immune cells during vascular inflammation leads to formation of leukotrienes (LTs). While macrophages represent a major source of LT biosynthesis in the proximity of the vascular wall, activated T lymphocytes may, in addition, play a key regulatory role on macrophage expression o...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2007.187 |
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| _version_ | 1850208855913398272 |
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| author | Magnus Bäck |
| author_facet | Magnus Bäck |
| author_sort | Magnus Bäck |
| collection | DOAJ |
| description | The accumulation of immune cells during vascular inflammation leads to formation of leukotrienes (LTs). While macrophages represent a major source of LT biosynthesis in the proximity of the vascular wall, activated T lymphocytes may, in addition, play a key regulatory role on macrophage expression of LT-forming enzymes. Within the vascular wall, LTs activate cell surface receptors of the BLT and CysLT subtypes expressed on vascular smooth muscle and endothelial cells. The LT receptor expression on those cells is highly dependent on transcriptional regulation by pro- and anti-inflammatory mediators. LT receptor activation on vascular smooth muscle cells is associated with both directly and indirectly induced vasoconstriction, as well as intimal hyperplasia through stimulation of migration and proliferation. On the other hand, endothelial LT receptors induce vasorelaxation and leukocyte recruitment and adhesion. Results from in vitro and in vivo studies of LT receptor antagonists indicate potential beneficial effects in atherosclerosis and other inflammatory cardiovascular diseases. |
| format | Article |
| id | doaj-art-91aec00b88b94e08bb71309d974e4eeb |
| institution | OA Journals |
| issn | 1537-744X |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-91aec00b88b94e08bb71309d974e4eeb2025-08-20T02:10:09ZengWileyThe Scientific World Journal1537-744X2007-01-0171422143910.1100/tsw.2007.187Leukotriene Receptors: Crucial Components in Vascular InflammationMagnus Bäck0Department of Cardiology Center for Molecular Medicine, Karolinska University Hospital, L8:03, 171 76 Stockholm, SwedenThe accumulation of immune cells during vascular inflammation leads to formation of leukotrienes (LTs). While macrophages represent a major source of LT biosynthesis in the proximity of the vascular wall, activated T lymphocytes may, in addition, play a key regulatory role on macrophage expression of LT-forming enzymes. Within the vascular wall, LTs activate cell surface receptors of the BLT and CysLT subtypes expressed on vascular smooth muscle and endothelial cells. The LT receptor expression on those cells is highly dependent on transcriptional regulation by pro- and anti-inflammatory mediators. LT receptor activation on vascular smooth muscle cells is associated with both directly and indirectly induced vasoconstriction, as well as intimal hyperplasia through stimulation of migration and proliferation. On the other hand, endothelial LT receptors induce vasorelaxation and leukocyte recruitment and adhesion. Results from in vitro and in vivo studies of LT receptor antagonists indicate potential beneficial effects in atherosclerosis and other inflammatory cardiovascular diseases.http://dx.doi.org/10.1100/tsw.2007.187 |
| spellingShingle | Magnus Bäck Leukotriene Receptors: Crucial Components in Vascular Inflammation The Scientific World Journal |
| title | Leukotriene Receptors: Crucial Components in Vascular Inflammation |
| title_full | Leukotriene Receptors: Crucial Components in Vascular Inflammation |
| title_fullStr | Leukotriene Receptors: Crucial Components in Vascular Inflammation |
| title_full_unstemmed | Leukotriene Receptors: Crucial Components in Vascular Inflammation |
| title_short | Leukotriene Receptors: Crucial Components in Vascular Inflammation |
| title_sort | leukotriene receptors crucial components in vascular inflammation |
| url | http://dx.doi.org/10.1100/tsw.2007.187 |
| work_keys_str_mv | AT magnusback leukotrienereceptorscrucialcomponentsinvascularinflammation |