New homocysteine consumption assay for high-throughput screening of human cystathionine-β-synthase

New homocysteine consumption assay for high-throughput screening of human cystathionine-β-synthase

Hyperhomocysteinemia is a risk factor for cardiovascular disease, neurological disorders, and bone abnormalities. The key enzyme in homocysteine metabolism, cystathionine-β-synthase (CBS) is recognized as a target for new homocysteine-lowering therapies including enzyme replacement and gene therapy....

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Bibliographic Details
Main Authors: Dalibor Nakládal, Rick Oerlemans, Miroslava Molitorisová, Nikola Chomaničová, Gabriel Zorkócy, Christina Yoseif, Adrianus Cornelis van der Graaf, Stanislav Stuchlík, Guido Krenning, Matthew R. Groves, André Heeres, Zdenko Levarski, Ján Kyselovič, Rob H. Henning, Leo E. Deelman
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:SLAS Discovery
Subjects:
Homocysteine
Hyperhomocysteinemia
Cystathionine-β-synthase
Assay development
High-throughput screening
Online Access:http://www.sciencedirect.com/science/article/pii/S2472555225000279
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