Phytosomes – an Effective Drug-Delivery System. Development, Technology, Application.
Herbal ingredients are widely used in practice due to their broad pharmacological effects and absence of side effects. However, despite their remarkable pharmacodynamic activity, most of the herbal ingredients have shown lower bioavailability in vivo conditions. New drug-delivery systems acquired v...
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| Format: | Article |
| Language: | English |
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al-Farabi Kazakh National University
2024-12-01
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| Series: | Eurasian Chemico-Technological Journal |
| Subjects: | |
| Online Access: | https://ect-journal.kz/index.php/ectj/article/view/1658 |
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| author | I.A. Khabarov S.D. Sergazy A.S. Maikenova A.N. Zhabayeva O.V. Maslova S.M. Adekenov |
| author_facet | I.A. Khabarov S.D. Sergazy A.S. Maikenova A.N. Zhabayeva O.V. Maslova S.M. Adekenov |
| author_sort | I.A. Khabarov |
| collection | DOAJ |
| description |
Herbal ingredients are widely used in practice due to their broad pharmacological effects and absence of side effects. However, despite their remarkable pharmacodynamic activity, most of the herbal ingredients have shown lower bioavailability in vivo conditions. New drug-delivery systems acquired vital importance because of higher bioavailability and overall therapeutic efficacy. A review of various studies on the production and application of phytosomal medical forms, which are in the form of hybrid molecules with high solubility in lipid and aqueous environments, is presented in this article. In an aquatic environment phytosomes group and form micelles. Phytosomes are used for increasing the bioavailability of the medical component, targeted delivery, and increasing the effect of the action of a medical drug while decreasing its therapeutic dose. Expanding the range of phytosomal medicinal forms, including sesquiterpene lactones, flavonoids, and other hydrophilic compounds is a perspective direction. In literary sources, methods for establishing quality control are practically absent and require development as well as unification.
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| format | Article |
| id | doaj-art-91902a25d5fc4391afcbaeca343fc9c6 |
| institution | Kabale University |
| issn | 1562-3920 2522-4867 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | al-Farabi Kazakh National University |
| record_format | Article |
| series | Eurasian Chemico-Technological Journal |
| spelling | doaj-art-91902a25d5fc4391afcbaeca343fc9c62025-01-29T15:42:07Zengal-Farabi Kazakh National UniversityEurasian Chemico-Technological Journal1562-39202522-48672024-12-0126410.18321/ectj1647Phytosomes – an Effective Drug-Delivery System. Development, Technology, Application.I.A. Khabarov0S.D. Sergazy1A.S. Maikenova2A.N. Zhabayeva3O.V. Maslova4S.M. Adekenov5JSC “Research and Production Center “Phytochemistry”, 4, M. Gazaliyev Str., Karaganda, KazakhstanJSC “Research and Production Center “Phytochemistry”, 4, M. Gazaliyev Str., Karaganda, KazakhstanJSC “Research and Production Center “Phytochemistry”, 4, M. Gazaliyev Str., Karaganda, KazakhstanJSC “Research and Production Center “Phytochemistry”, 4, M. Gazaliyev Str., Karaganda, KazakhstanJSC “Research and Production Center “Phytochemistry”, 4, M. Gazaliyev Str., Karaganda, KazakhstanJSC “Research and Production Center “Phytochemistry”, 4, M. Gazaliyev Str., Karaganda, Kazakhstan Herbal ingredients are widely used in practice due to their broad pharmacological effects and absence of side effects. However, despite their remarkable pharmacodynamic activity, most of the herbal ingredients have shown lower bioavailability in vivo conditions. New drug-delivery systems acquired vital importance because of higher bioavailability and overall therapeutic efficacy. A review of various studies on the production and application of phytosomal medical forms, which are in the form of hybrid molecules with high solubility in lipid and aqueous environments, is presented in this article. In an aquatic environment phytosomes group and form micelles. Phytosomes are used for increasing the bioavailability of the medical component, targeted delivery, and increasing the effect of the action of a medical drug while decreasing its therapeutic dose. Expanding the range of phytosomal medicinal forms, including sesquiterpene lactones, flavonoids, and other hydrophilic compounds is a perspective direction. In literary sources, methods for establishing quality control are practically absent and require development as well as unification. https://ect-journal.kz/index.php/ectj/article/view/1658PhytosomePhosphatidylcholinePhosphatidylethanolaminePhosphatidylserineProduction methodsBioavailability |
| spellingShingle | I.A. Khabarov S.D. Sergazy A.S. Maikenova A.N. Zhabayeva O.V. Maslova S.M. Adekenov Phytosomes – an Effective Drug-Delivery System. Development, Technology, Application. Eurasian Chemico-Technological Journal Phytosome Phosphatidylcholine Phosphatidylethanolamine Phosphatidylserine Production methods Bioavailability |
| title | Phytosomes – an Effective Drug-Delivery System. Development, Technology, Application. |
| title_full | Phytosomes – an Effective Drug-Delivery System. Development, Technology, Application. |
| title_fullStr | Phytosomes – an Effective Drug-Delivery System. Development, Technology, Application. |
| title_full_unstemmed | Phytosomes – an Effective Drug-Delivery System. Development, Technology, Application. |
| title_short | Phytosomes – an Effective Drug-Delivery System. Development, Technology, Application. |
| title_sort | phytosomes an effective drug delivery system development technology application |
| topic | Phytosome Phosphatidylcholine Phosphatidylethanolamine Phosphatidylserine Production methods Bioavailability |
| url | https://ect-journal.kz/index.php/ectj/article/view/1658 |
| work_keys_str_mv | AT iakhabarov phytosomesaneffectivedrugdeliverysystemdevelopmenttechnologyapplication AT sdsergazy phytosomesaneffectivedrugdeliverysystemdevelopmenttechnologyapplication AT asmaikenova phytosomesaneffectivedrugdeliverysystemdevelopmenttechnologyapplication AT anzhabayeva phytosomesaneffectivedrugdeliverysystemdevelopmenttechnologyapplication AT ovmaslova phytosomesaneffectivedrugdeliverysystemdevelopmenttechnologyapplication AT smadekenov phytosomesaneffectivedrugdeliverysystemdevelopmenttechnologyapplication |