A Chlorin e6 derivative-mediated photodynamic therapy versus doxycycline for moderate-to-severe rosacea: A prospective, randomized, controlled study
Background: Photodynamic therapy (PDT) is beneficial for managing rosacea, and chlorin e6 derivative-mediated photodynamic therapy (STBF-PDT) has demonstrated efficacy in reducing acne lesions with mild adverse reactions. Objectives: This study aimed to assess the effectiveness and safety of STBF-PD...
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Elsevier
2025-02-01
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| Series: | Photodiagnosis and Photodynamic Therapy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1572100025000043 |
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| author | Yun Wu Qing Fan Xiaojing Liu Yajing Cao Jin Yang Yu Yan Hui Tao Fuhe Zhang Linglin Zhang Peiru Wang Xiuli Wang |
| author_facet | Yun Wu Qing Fan Xiaojing Liu Yajing Cao Jin Yang Yu Yan Hui Tao Fuhe Zhang Linglin Zhang Peiru Wang Xiuli Wang |
| author_sort | Yun Wu |
| collection | DOAJ |
| description | Background: Photodynamic therapy (PDT) is beneficial for managing rosacea, and chlorin e6 derivative-mediated photodynamic therapy (STBF-PDT) has demonstrated efficacy in reducing acne lesions with mild adverse reactions. Objectives: This study aimed to assess the effectiveness and safety of STBF-PDT for the treatment of moderate-to-severe rosacea. Methods: In this prospective, randomised, evaluator-blind controlled study, patients with moderate-to-severe rosacea were assigned to receive up to six STBF-PDT sessions or 100 mg of doxycycline daily for eight weeks, followed by a 24-week follow-up. Results: A total of 76 patients were enrolled (38 assigned to STBF-PDT and 38 to oral doxycycline) with 69 (36 in the STBF-PDT group and 33 in the doxycycline group) completing the study. At the end of treatment, the median reduction in lesion count was 82.3 % in the STBF-PDT group and 81.8 % in the doxycycline group, indicating no significant difference between the groups. The STBF-PDT group exhibited a lower relapse rate and a significantly higher reduction in Demodex mites. Clinician's Erythema Assessment success (CEA), sensations of burning and pruritus, telangiectasia, and Rosacea-related Quality of Life (RosaQoL) scores were comparable between groups. No severe adverse reactions were observed. Conclusions: STBF-PDT is a promising treatment option for mild-to-moderate rosacea with mild adverse reactions. |
| format | Article |
| id | doaj-art-917a679e9b604c599c32f4367603dd82 |
| institution | Kabale University |
| issn | 1572-1000 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Photodiagnosis and Photodynamic Therapy |
| spelling | doaj-art-917a679e9b604c599c32f4367603dd822025-02-01T04:11:50ZengElsevierPhotodiagnosis and Photodynamic Therapy1572-10002025-02-0151104474A Chlorin e6 derivative-mediated photodynamic therapy versus doxycycline for moderate-to-severe rosacea: A prospective, randomized, controlled studyYun Wu0Qing Fan1Xiaojing Liu2Yajing Cao3Jin Yang4Yu Yan5Hui Tao6Fuhe Zhang7Linglin Zhang8Peiru Wang9Xiuli Wang10Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, ChinaDepartment of Dermatology, Shanghai Fengxian District Central Hospital, Shanghai, 201499, ChinaInstitute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, ChinaInstitute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, ChinaInstitute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, ChinaInstitute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, ChinaInstitute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, ChinaDepartment of Dermatology, Shanghai Fengxian District Central Hospital, Shanghai, 201499, ChinaInstitute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, China; Corresponding authors.Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, China; Corresponding authors.Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 200443, China; Corresponding authors.Background: Photodynamic therapy (PDT) is beneficial for managing rosacea, and chlorin e6 derivative-mediated photodynamic therapy (STBF-PDT) has demonstrated efficacy in reducing acne lesions with mild adverse reactions. Objectives: This study aimed to assess the effectiveness and safety of STBF-PDT for the treatment of moderate-to-severe rosacea. Methods: In this prospective, randomised, evaluator-blind controlled study, patients with moderate-to-severe rosacea were assigned to receive up to six STBF-PDT sessions or 100 mg of doxycycline daily for eight weeks, followed by a 24-week follow-up. Results: A total of 76 patients were enrolled (38 assigned to STBF-PDT and 38 to oral doxycycline) with 69 (36 in the STBF-PDT group and 33 in the doxycycline group) completing the study. At the end of treatment, the median reduction in lesion count was 82.3 % in the STBF-PDT group and 81.8 % in the doxycycline group, indicating no significant difference between the groups. The STBF-PDT group exhibited a lower relapse rate and a significantly higher reduction in Demodex mites. Clinician's Erythema Assessment success (CEA), sensations of burning and pruritus, telangiectasia, and Rosacea-related Quality of Life (RosaQoL) scores were comparable between groups. No severe adverse reactions were observed. Conclusions: STBF-PDT is a promising treatment option for mild-to-moderate rosacea with mild adverse reactions.http://www.sciencedirect.com/science/article/pii/S1572100025000043Photodynamic therapyRosaceaErythemaPapulopustularDoxycycline |
| spellingShingle | Yun Wu Qing Fan Xiaojing Liu Yajing Cao Jin Yang Yu Yan Hui Tao Fuhe Zhang Linglin Zhang Peiru Wang Xiuli Wang A Chlorin e6 derivative-mediated photodynamic therapy versus doxycycline for moderate-to-severe rosacea: A prospective, randomized, controlled study Photodiagnosis and Photodynamic Therapy Photodynamic therapy Rosacea Erythema Papulopustular Doxycycline |
| title | A Chlorin e6 derivative-mediated photodynamic therapy versus doxycycline for moderate-to-severe rosacea: A prospective, randomized, controlled study |
| title_full | A Chlorin e6 derivative-mediated photodynamic therapy versus doxycycline for moderate-to-severe rosacea: A prospective, randomized, controlled study |
| title_fullStr | A Chlorin e6 derivative-mediated photodynamic therapy versus doxycycline for moderate-to-severe rosacea: A prospective, randomized, controlled study |
| title_full_unstemmed | A Chlorin e6 derivative-mediated photodynamic therapy versus doxycycline for moderate-to-severe rosacea: A prospective, randomized, controlled study |
| title_short | A Chlorin e6 derivative-mediated photodynamic therapy versus doxycycline for moderate-to-severe rosacea: A prospective, randomized, controlled study |
| title_sort | chlorin e6 derivative mediated photodynamic therapy versus doxycycline for moderate to severe rosacea a prospective randomized controlled study |
| topic | Photodynamic therapy Rosacea Erythema Papulopustular Doxycycline |
| url | http://www.sciencedirect.com/science/article/pii/S1572100025000043 |
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