Gestational diabetes in early pregnancy is associated with postpartum glucose intolerance: A perspective from the diabetes and pregnancy outcome for mother and baby study in Japan

Gestational diabetes in early pregnancy is associated with postpartum glucose intolerance: A perspective from the diabetes and pregnancy outcome for mother and baby study in Japan

ABSTRACT Aims To compare perinatal outcomes and postpartum glucose tolerance between women diagnosed with gestational diabetes mellitus (GDM) before 20 weeks of gestation (EGDM) and those diagnosed at or after 24 weeks of gestation (LGDM) in a Japanese population. Materials and Methods Data were obt...

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Main Authors: Maki Yokoyama, Kei Miyakoshi, Noriyuki Iwama, Hiroshi Yamashita, Ichiro Yasuhi, Maki Kawasaki, Naoko Arata, Shiori Sato, Yuko Imura, Masako Waguri, Haruna Kawaguchi, Naoki Masaoka, Yoshiyuki Nakajima, Yuji Hiramatsu, Takashi Sugiyama, DREAMBee Study Gestational Diabetes Mellitus Group
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Journal of Diabetes Investigation
Subjects:
Gestational diabetes mellitus in early pregnancy
Overweight/obesity
Postpartum glucose intolerance
Online Access:https://doi.org/10.1111/jdi.14368
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Summary:ABSTRACT Aims To compare perinatal outcomes and postpartum glucose tolerance between women diagnosed with gestational diabetes mellitus (GDM) before 20 weeks of gestation (EGDM) and those diagnosed at or after 24 weeks of gestation (LGDM) in a Japanese population. Materials and Methods Data were obtained from a prospective GDM registry. Multivariate analysis was conducted to examine the association between the timing of GDM diagnosis (EGDM vs LGDM) and perinatal outcomes (preterm birth, small for gestational age, large for gestational age, pregnancy‐induced hypertension, and neonatal hypoglycemia), as well as postpartum glucose intolerance. Results A total of 1,275 mother‐infant pairs were analyzed for perinatal outcomes. Of these, 924 women underwent postpartum testing for glucose intolerance. No significant differences in perinatal outcomes were observed between the EGDM and LGDM groups, except that overweight/obese women with EGDM had 2.5‐fold higher rate of preterm birth than those with LGDM. Postpartum glucose intolerance was 1.5 times more likely in the EGDM group than in the LGDM group. Conclusions Women with EGDM had a significantly higher risk of postpartum glucose intolerance than those with LGDM, despite similar perinatal outcomes between the two groups.
ISSN:2040-1116
2040-1124

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