Rapid Onset Severe Immune Thrombocytopenia following mRNA COVID-19 Vaccine in a Young Patient
The coronavirus disease 2019 (COVID-19) pandemic has affected millions of people around the world. Vaccination against COVID-19 has been approved for the following three vaccines in the United States: Pfizer-BioNTech, Moderna, and Janssen. Hematological complications of vaccination have been reporte...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2023/7877536 |
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| author | Jorge Avila Huseyin Berk Degirmenci Pamela Contreras Chavez Elisabeth M. Battinelli Jorge Fleisher |
| author_facet | Jorge Avila Huseyin Berk Degirmenci Pamela Contreras Chavez Elisabeth M. Battinelli Jorge Fleisher |
| author_sort | Jorge Avila |
| collection | DOAJ |
| description | The coronavirus disease 2019 (COVID-19) pandemic has affected millions of people around the world. Vaccination against COVID-19 has been approved for the following three vaccines in the United States: Pfizer-BioNTech, Moderna, and Janssen. Hematological complications of vaccination have been reported in the literature but remain as a rare phenomenon. We present the case of a patient who developed severe thrombocytopenia within twenty-four hours following the Pfizer-BioNTech vaccination. Commonly encountered differentials including heparin-induced thrombocytopenia and common viral etiologies were ruled out, and other causes such as drug reactions deemed unlikely as the etiology of this presentation after a broad workup. Nucleocapsid antibodies against COVID-19 were found to be positive which indicated that vaccination was at least the second encounter with this virus for our patient, which has been reported previously as the cause of immune thrombocytopenia (ITP), and this might be the culprit for sudden onset. He responded to the first-line ITP treatment with corticosteroids and intravenous immunoglobulin (IVIG) as evidenced by the fast recovery of platelet count and lack of recurrence of thrombocytopenia. |
| format | Article |
| id | doaj-art-91646e559fc44560bca728c56cbb4f96 |
| institution | Kabale University |
| issn | 2090-6579 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-91646e559fc44560bca728c56cbb4f962025-02-03T06:42:51ZengWileyCase Reports in Hematology2090-65792023-01-01202310.1155/2023/7877536Rapid Onset Severe Immune Thrombocytopenia following mRNA COVID-19 Vaccine in a Young PatientJorge Avila0Huseyin Berk Degirmenci1Pamela Contreras Chavez2Elisabeth M. Battinelli3Jorge Fleisher4Department of MedicineDepartment of MedicineDana Farber Cancer Institute at St. Elizabeth’s Medical CenterDivision of HematologyDepartment of MedicineThe coronavirus disease 2019 (COVID-19) pandemic has affected millions of people around the world. Vaccination against COVID-19 has been approved for the following three vaccines in the United States: Pfizer-BioNTech, Moderna, and Janssen. Hematological complications of vaccination have been reported in the literature but remain as a rare phenomenon. We present the case of a patient who developed severe thrombocytopenia within twenty-four hours following the Pfizer-BioNTech vaccination. Commonly encountered differentials including heparin-induced thrombocytopenia and common viral etiologies were ruled out, and other causes such as drug reactions deemed unlikely as the etiology of this presentation after a broad workup. Nucleocapsid antibodies against COVID-19 were found to be positive which indicated that vaccination was at least the second encounter with this virus for our patient, which has been reported previously as the cause of immune thrombocytopenia (ITP), and this might be the culprit for sudden onset. He responded to the first-line ITP treatment with corticosteroids and intravenous immunoglobulin (IVIG) as evidenced by the fast recovery of platelet count and lack of recurrence of thrombocytopenia.http://dx.doi.org/10.1155/2023/7877536 |
| spellingShingle | Jorge Avila Huseyin Berk Degirmenci Pamela Contreras Chavez Elisabeth M. Battinelli Jorge Fleisher Rapid Onset Severe Immune Thrombocytopenia following mRNA COVID-19 Vaccine in a Young Patient Case Reports in Hematology |
| title | Rapid Onset Severe Immune Thrombocytopenia following mRNA COVID-19 Vaccine in a Young Patient |
| title_full | Rapid Onset Severe Immune Thrombocytopenia following mRNA COVID-19 Vaccine in a Young Patient |
| title_fullStr | Rapid Onset Severe Immune Thrombocytopenia following mRNA COVID-19 Vaccine in a Young Patient |
| title_full_unstemmed | Rapid Onset Severe Immune Thrombocytopenia following mRNA COVID-19 Vaccine in a Young Patient |
| title_short | Rapid Onset Severe Immune Thrombocytopenia following mRNA COVID-19 Vaccine in a Young Patient |
| title_sort | rapid onset severe immune thrombocytopenia following mrna covid 19 vaccine in a young patient |
| url | http://dx.doi.org/10.1155/2023/7877536 |
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