Acute High Dose Melatonin for Encephalopathy of the Newborn (ACUMEN) Study: a protocol for a multicentre phase 1 safety trial of melatonin to augment therapeutic hypothermia for moderate/severe hypoxic ischaemic encephalopathy

Acute High Dose Melatonin for Encephalopathy of the Newborn (ACUMEN) Study: a protocol for a multicentre phase 1 safety trial of melatonin to augment therapeutic hypothermia for moderate/severe hypoxic ischaemic encephalopathy

Introduction Neonatal death and later disability remain common sequelae of hypoxic-ischaemic encephalopathy (HIE) despite the now standard use of therapeutic hypothermia (HT). New therapeutic approaches to brain protection are required. Melatonin is an indolamine hormone with free-radical scavenging...

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Main Authors: Neil Marlow, Adrienne Foran, Deirdre M Murray, Eleanor J Molloy, James P Boardman, Atul Malhotra, Geraldine Boylan, Subhabrata Mitra, Nicola J Robertson, Karel Allegaert, Suzanne L Miller, Anne Smits, Frances Cowan, Joseph F Standing, Giles Kendall, Rodney W Hunt, Hakim-Moulay Dehbi, Julie-Clare Becher, Linda De Vries, Divyen Shah, Alyson MacNeil, Anvi Wadke, Raymand Pang, Yusuf Jaami, Pamela Tranter, Ajit K Mahaveer, Kathryn A Martinello, Balamurugan Palanisami, Brian Walsh
Format: Article
Language:English
Published: BMJ Publishing Group 2025-08-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/8/e107083.full
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