Immunoregulation of NKT Cells in Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with different variety of clinical manifestations. Natural killer T (NKT) cells are innate lymphocytes that play a regulatory role during broad range of immune responses. A number of studies demonstrated that the quantity and qua...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/206731 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832553344665649152 |
|---|---|
| author | Junwei Chen Meng Wu Jing Wang Xiaofeng Li |
| author_facet | Junwei Chen Meng Wu Jing Wang Xiaofeng Li |
| author_sort | Junwei Chen |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with different variety of clinical manifestations. Natural killer T (NKT) cells are innate lymphocytes that play a regulatory role during broad range of immune responses. A number of studies demonstrated that the quantity and quality of invariant NKT (iNKT) cells showed marked defects in SLE patients in comparison to healthy controls. This finding suggests that iNKT cells may play a regulatory role in the occurrence and development of this disease. In this review, we mainly summarized the most recent findings about the behavior of NKT cells in SLE patients and mouse models, as well as how NKT cells affect the proportion of T helper cells and the production of autoreactive antibodies in the progress of SLE. This will help people better understand the role of NKT cells in the development of SLE and improve the therapy strategy. |
| format | Article |
| id | doaj-art-915ab9176f4b480bb8bb1a315c2ad351 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-915ab9176f4b480bb8bb1a315c2ad3512025-02-03T05:54:10ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/206731206731Immunoregulation of NKT Cells in Systemic Lupus ErythematosusJunwei Chen0Meng Wu1Jing Wang2Xiaofeng Li3Department of Rheumatology, The Second Hospital of Shanxi Medical University, Shanxi, Taiyuan 030001, ChinaDepartment of Rheumatology, The Second Hospital of Shanxi Medical University, Shanxi, Taiyuan 030001, ChinaDepartment of Rheumatology, The Second Hospital of Shanxi Medical University, Shanxi, Taiyuan 030001, ChinaDepartment of Rheumatology, The Second Hospital of Shanxi Medical University, Shanxi, Taiyuan 030001, ChinaSystemic lupus erythematosus (SLE) is a multisystem autoimmune disease with different variety of clinical manifestations. Natural killer T (NKT) cells are innate lymphocytes that play a regulatory role during broad range of immune responses. A number of studies demonstrated that the quantity and quality of invariant NKT (iNKT) cells showed marked defects in SLE patients in comparison to healthy controls. This finding suggests that iNKT cells may play a regulatory role in the occurrence and development of this disease. In this review, we mainly summarized the most recent findings about the behavior of NKT cells in SLE patients and mouse models, as well as how NKT cells affect the proportion of T helper cells and the production of autoreactive antibodies in the progress of SLE. This will help people better understand the role of NKT cells in the development of SLE and improve the therapy strategy.http://dx.doi.org/10.1155/2015/206731 |
| spellingShingle | Junwei Chen Meng Wu Jing Wang Xiaofeng Li Immunoregulation of NKT Cells in Systemic Lupus Erythematosus Journal of Immunology Research |
| title | Immunoregulation of NKT Cells in Systemic Lupus Erythematosus |
| title_full | Immunoregulation of NKT Cells in Systemic Lupus Erythematosus |
| title_fullStr | Immunoregulation of NKT Cells in Systemic Lupus Erythematosus |
| title_full_unstemmed | Immunoregulation of NKT Cells in Systemic Lupus Erythematosus |
| title_short | Immunoregulation of NKT Cells in Systemic Lupus Erythematosus |
| title_sort | immunoregulation of nkt cells in systemic lupus erythematosus |
| url | http://dx.doi.org/10.1155/2015/206731 |
| work_keys_str_mv | AT junweichen immunoregulationofnktcellsinsystemiclupuserythematosus AT mengwu immunoregulationofnktcellsinsystemiclupuserythematosus AT jingwang immunoregulationofnktcellsinsystemiclupuserythematosus AT xiaofengli immunoregulationofnktcellsinsystemiclupuserythematosus |