Impact of Microbiota on Irritable Bowel Syndrome Pathogenesis and Management: A Narrative Review
Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder, affecting 3–5% of the global population and significantly impacting patients’ quality of life and healthcare resources. Alongside physical symptoms such as abdominal pain and altered bowel habits, many individuals experience ps...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/61/1/109 |
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| author | Mhd Bashir Almonajjed Mahdi Wardeh Abdallah Atlagh Abdulrahman Ismaiel Stefan-Lucian Popa Flaviu Rusu Dan L. Dumitrascu |
| author_facet | Mhd Bashir Almonajjed Mahdi Wardeh Abdallah Atlagh Abdulrahman Ismaiel Stefan-Lucian Popa Flaviu Rusu Dan L. Dumitrascu |
| author_sort | Mhd Bashir Almonajjed |
| collection | DOAJ |
| description | Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder, affecting 3–5% of the global population and significantly impacting patients’ quality of life and healthcare resources. Alongside physical symptoms such as abdominal pain and altered bowel habits, many individuals experience psychological comorbidities, including anxiety and depression. Recent research has highlighted the critical role of the gut microbiota in IBS, with dysbiosis, characterized by an imbalance in microbial diversity, frequently observed in patients. The gut–brain axis, a bidirectional communication network between the gut and central nervous system, plays a central role in the development of IBS symptoms. Although interventions such as probiotics, prebiotics, synbiotics, and fecal microbiota transplantation (FMT) have demonstrated potential in modulating the gut microbiota and alleviating symptoms, their efficacy remains an area of ongoing investigation. This review examines the interactions between the gut microbiota, immune system, and brain, emphasizing the need for personalized therapeutic strategies. Future research should aim to identify reliable microbiota-based biomarkers for IBS and refine microbiome-targeted therapies to enhance patient outcomes. |
| format | Article |
| id | doaj-art-9151ad69e9814d0285bf20b391423218 |
| institution | Kabale University |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj-art-9151ad69e9814d0285bf20b3914232182025-01-24T13:40:39ZengMDPI AGMedicina1010-660X1648-91442025-01-0161110910.3390/medicina61010109Impact of Microbiota on Irritable Bowel Syndrome Pathogenesis and Management: A Narrative ReviewMhd Bashir Almonajjed0Mahdi Wardeh1Abdallah Atlagh2Abdulrahman Ismaiel3Stefan-Lucian Popa4Flaviu Rusu5Dan L. Dumitrascu6Faculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400006 Cluj-Napoca, RomaniaFaculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400006 Cluj-Napoca, RomaniaFaculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania2nd Department of Internal Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania2nd Department of Internal Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania2nd Department of Internal Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania2nd Department of Internal Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400006 Cluj-Napoca, RomaniaIrritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder, affecting 3–5% of the global population and significantly impacting patients’ quality of life and healthcare resources. Alongside physical symptoms such as abdominal pain and altered bowel habits, many individuals experience psychological comorbidities, including anxiety and depression. Recent research has highlighted the critical role of the gut microbiota in IBS, with dysbiosis, characterized by an imbalance in microbial diversity, frequently observed in patients. The gut–brain axis, a bidirectional communication network between the gut and central nervous system, plays a central role in the development of IBS symptoms. Although interventions such as probiotics, prebiotics, synbiotics, and fecal microbiota transplantation (FMT) have demonstrated potential in modulating the gut microbiota and alleviating symptoms, their efficacy remains an area of ongoing investigation. This review examines the interactions between the gut microbiota, immune system, and brain, emphasizing the need for personalized therapeutic strategies. Future research should aim to identify reliable microbiota-based biomarkers for IBS and refine microbiome-targeted therapies to enhance patient outcomes.https://www.mdpi.com/1648-9144/61/1/109irritable bowel syndromemicrobiotagut–brain axisdisorders of gut brain interaction (DGBI) |
| spellingShingle | Mhd Bashir Almonajjed Mahdi Wardeh Abdallah Atlagh Abdulrahman Ismaiel Stefan-Lucian Popa Flaviu Rusu Dan L. Dumitrascu Impact of Microbiota on Irritable Bowel Syndrome Pathogenesis and Management: A Narrative Review Medicina irritable bowel syndrome microbiota gut–brain axis disorders of gut brain interaction (DGBI) |
| title | Impact of Microbiota on Irritable Bowel Syndrome Pathogenesis and Management: A Narrative Review |
| title_full | Impact of Microbiota on Irritable Bowel Syndrome Pathogenesis and Management: A Narrative Review |
| title_fullStr | Impact of Microbiota on Irritable Bowel Syndrome Pathogenesis and Management: A Narrative Review |
| title_full_unstemmed | Impact of Microbiota on Irritable Bowel Syndrome Pathogenesis and Management: A Narrative Review |
| title_short | Impact of Microbiota on Irritable Bowel Syndrome Pathogenesis and Management: A Narrative Review |
| title_sort | impact of microbiota on irritable bowel syndrome pathogenesis and management a narrative review |
| topic | irritable bowel syndrome microbiota gut–brain axis disorders of gut brain interaction (DGBI) |
| url | https://www.mdpi.com/1648-9144/61/1/109 |
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