Gastric Linitis Plastica and Peritoneal Carcinomatosis as First Manifestations of Occult Breast Carcinoma: A Case Report and Literature Review
Gastric linitis plastica is a diffuse involvement of the stomach walls by neoplastic cells. It represents about 3–19% of primitive gastric adenocarcinomas, but it can also be the manifestation of a metastatic disease. Breast cancer is the most frequent malignancy in women, and the metastatic spread...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2018/4714708 |
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| author | Mara Mantiero Giovanni Faggioni Alice Menichetti Matteo Fassan Valentina Guarneri Pierfranco Conte |
| author_facet | Mara Mantiero Giovanni Faggioni Alice Menichetti Matteo Fassan Valentina Guarneri Pierfranco Conte |
| author_sort | Mara Mantiero |
| collection | DOAJ |
| description | Gastric linitis plastica is a diffuse involvement of the stomach walls by neoplastic cells. It represents about 3–19% of primitive gastric adenocarcinomas, but it can also be the manifestation of a metastatic disease. Breast cancer is the most frequent malignancy in women, and the metastatic spread to the stomach occurs in less than 10% of the cases. We present an unusual case of gastric linitis plastica and peritoneal carcinomatosis as manifestations of an occult breast cancer in a 53-year-old woman. Imaging and endoscopic evaluation were not able to discriminate a primary from a secondary gastric lesion. The histological evaluation excluded the diagnosis of a primary gastric neoplasia. The IHC profile was consistent with the diagnosis of metastases from the breast cancer. Due to the hormonal receptors’ positivity, we started therapy with fulvestrant (500 mg, day 0, 14, and 28 and every 28 days thereafter by intramuscular injection). After 20 months, the same therapy is still ongoing and well tolerated, while the patient is in good condition with improvement of the dysphagia. Almost 2 years after the diagnosis of linitis plastica, the primitive breast lesion is still occult. |
| format | Article |
| id | doaj-art-914ae2e516d6485c9f0ba6b9f1d12a2d |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-914ae2e516d6485c9f0ba6b9f1d12a2d2025-02-03T01:12:48ZengWileyCase Reports in Oncological Medicine2090-67062090-67142018-01-01201810.1155/2018/47147084714708Gastric Linitis Plastica and Peritoneal Carcinomatosis as First Manifestations of Occult Breast Carcinoma: A Case Report and Literature ReviewMara Mantiero0Giovanni Faggioni1Alice Menichetti2Matteo Fassan3Valentina Guarneri4Pierfranco Conte5Medical Oncology Unit 2, Istituto Oncologico Veneto, IRCCS, Padova, ItalyMedical Oncology Unit 2, Istituto Oncologico Veneto, IRCCS, Padova, ItalyMedical Oncology Unit 2, Istituto Oncologico Veneto, IRCCS, Padova, ItalyDepartment of Medicine, Surgical Pathology & Cytopathology Unit, University of Padova, Padova, ItalyMedical Oncology Unit 2, Istituto Oncologico Veneto, IRCCS, Padova, ItalyMedical Oncology Unit 2, Istituto Oncologico Veneto, IRCCS, Padova, ItalyGastric linitis plastica is a diffuse involvement of the stomach walls by neoplastic cells. It represents about 3–19% of primitive gastric adenocarcinomas, but it can also be the manifestation of a metastatic disease. Breast cancer is the most frequent malignancy in women, and the metastatic spread to the stomach occurs in less than 10% of the cases. We present an unusual case of gastric linitis plastica and peritoneal carcinomatosis as manifestations of an occult breast cancer in a 53-year-old woman. Imaging and endoscopic evaluation were not able to discriminate a primary from a secondary gastric lesion. The histological evaluation excluded the diagnosis of a primary gastric neoplasia. The IHC profile was consistent with the diagnosis of metastases from the breast cancer. Due to the hormonal receptors’ positivity, we started therapy with fulvestrant (500 mg, day 0, 14, and 28 and every 28 days thereafter by intramuscular injection). After 20 months, the same therapy is still ongoing and well tolerated, while the patient is in good condition with improvement of the dysphagia. Almost 2 years after the diagnosis of linitis plastica, the primitive breast lesion is still occult.http://dx.doi.org/10.1155/2018/4714708 |
| spellingShingle | Mara Mantiero Giovanni Faggioni Alice Menichetti Matteo Fassan Valentina Guarneri Pierfranco Conte Gastric Linitis Plastica and Peritoneal Carcinomatosis as First Manifestations of Occult Breast Carcinoma: A Case Report and Literature Review Case Reports in Oncological Medicine |
| title | Gastric Linitis Plastica and Peritoneal Carcinomatosis as First Manifestations of Occult Breast Carcinoma: A Case Report and Literature Review |
| title_full | Gastric Linitis Plastica and Peritoneal Carcinomatosis as First Manifestations of Occult Breast Carcinoma: A Case Report and Literature Review |
| title_fullStr | Gastric Linitis Plastica and Peritoneal Carcinomatosis as First Manifestations of Occult Breast Carcinoma: A Case Report and Literature Review |
| title_full_unstemmed | Gastric Linitis Plastica and Peritoneal Carcinomatosis as First Manifestations of Occult Breast Carcinoma: A Case Report and Literature Review |
| title_short | Gastric Linitis Plastica and Peritoneal Carcinomatosis as First Manifestations of Occult Breast Carcinoma: A Case Report and Literature Review |
| title_sort | gastric linitis plastica and peritoneal carcinomatosis as first manifestations of occult breast carcinoma a case report and literature review |
| url | http://dx.doi.org/10.1155/2018/4714708 |
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