Identification of CTSC-driven progression in ESCC by single-cell sequencing and experimental validation

Identification of CTSC-driven progression in ESCC by single-cell sequencing and experimental validation

BackgroundThe progression of cancer cells is influenced by the tumor microenvironment (TME); however, the molecular mechanisms driving the progression of esophageal squamous cell carcinoma (ESCC) remain unclear. Therefore, we aimed to investigate the TME of ESCC and construct a risk signature based...

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Bibliographic Details
Main Authors: Xin Sui, Yongxu Jia, Jing Li, Jiayao Xu, Wenjia Wang, Yanru Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
esophageal squamous cell carcinoma
tumor microenvironment
single cell RNA sequencing
malignant cell
apoptosis
CTSC
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1585139/full
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