Prognostic Value of Adrenomedullin and Natriuretic Peptides in Uroseptic Patients Induced by Ureteroscopy
The aim of this paper is to investigate whether urosepsis is related to irrigation pressure of ureteroscopy (URS) and evaluate the prognostic value of adrenomedullin (ADM) and atrial and brain natriuretic peptides (ANP and BNP) in URS-induced uroseptic patients. From July 2008 to October 2013, we en...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/9743198 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832561230718435328 |
|---|---|
| author | Wei Hu Pang-hu Zhou Wei Wang Lijun Zhang Xiao-bin Zhang |
| author_facet | Wei Hu Pang-hu Zhou Wei Wang Lijun Zhang Xiao-bin Zhang |
| author_sort | Wei Hu |
| collection | DOAJ |
| description | The aim of this paper is to investigate whether urosepsis is related to irrigation pressure of ureteroscopy (URS) and evaluate the prognostic value of adrenomedullin (ADM) and atrial and brain natriuretic peptides (ANP and BNP) in URS-induced uroseptic patients. From July 2008 to October 2013, we enrolled 332 patients with untreated unilateral ureteral obstruction (UUO). The UUO group included three subgroups of, respectively, 118, 132, and 82 patients who underwent URS under intermittent stable irrigation pressure of, respectively, 80, 120, and 160 mmHg. The plasma concentrations of ADM, ANP, and BNP were measured in all subjects. URS was performed for all UUO patients; the values of the three peptides were measured again after URS. Irrigation pressure and stone size were independent risk factors of urosepsis. After URS, the plasma concentrations of ADM, ANP, and BNP were significantly higher in uroseptic patients. Moreover, the concentrations were significantly higher depending on the disease severity. Plasma concentrations of the three peptides were correlated with plasma ET concentration in the uroseptic patients. The areas under receiver operating characteristic (ROC) curve of ADM, ANP, and BNP for predicting urosepsis were 0.811, 0.728, and 0.764, respectively. In conclusion, ADM, along with ANP and BNP, is valuable for prognosis in urosepsis secondary to URS which is associated with irrigation pressure. |
| format | Article |
| id | doaj-art-913083d3cf9f47b0a01c403288b32b5a |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-913083d3cf9f47b0a01c403288b32b5a2025-02-03T01:25:37ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/97431989743198Prognostic Value of Adrenomedullin and Natriuretic Peptides in Uroseptic Patients Induced by UreteroscopyWei Hu0Pang-hu Zhou1Wei Wang2Lijun Zhang3Xiao-bin Zhang4Department of Urology, Renmin Hospital of Wuhan University, No. 238 Liberation Road, Wuhan, Hubei 430060, ChinaDepartment of Orthopedics, Renmin Hospital of Wuhan University, No. 238 Liberation Road, Wuhan, Hubei 430060, ChinaDepartment of Urology, Renmin Hospital of Wuhan University, No. 238 Liberation Road, Wuhan, Hubei 430060, ChinaDepartment of Urology, Renmin Hospital of Wuhan University, No. 238 Liberation Road, Wuhan, Hubei 430060, ChinaDepartment of Urology, Renmin Hospital of Wuhan University, No. 238 Liberation Road, Wuhan, Hubei 430060, ChinaThe aim of this paper is to investigate whether urosepsis is related to irrigation pressure of ureteroscopy (URS) and evaluate the prognostic value of adrenomedullin (ADM) and atrial and brain natriuretic peptides (ANP and BNP) in URS-induced uroseptic patients. From July 2008 to October 2013, we enrolled 332 patients with untreated unilateral ureteral obstruction (UUO). The UUO group included three subgroups of, respectively, 118, 132, and 82 patients who underwent URS under intermittent stable irrigation pressure of, respectively, 80, 120, and 160 mmHg. The plasma concentrations of ADM, ANP, and BNP were measured in all subjects. URS was performed for all UUO patients; the values of the three peptides were measured again after URS. Irrigation pressure and stone size were independent risk factors of urosepsis. After URS, the plasma concentrations of ADM, ANP, and BNP were significantly higher in uroseptic patients. Moreover, the concentrations were significantly higher depending on the disease severity. Plasma concentrations of the three peptides were correlated with plasma ET concentration in the uroseptic patients. The areas under receiver operating characteristic (ROC) curve of ADM, ANP, and BNP for predicting urosepsis were 0.811, 0.728, and 0.764, respectively. In conclusion, ADM, along with ANP and BNP, is valuable for prognosis in urosepsis secondary to URS which is associated with irrigation pressure.http://dx.doi.org/10.1155/2016/9743198 |
| spellingShingle | Wei Hu Pang-hu Zhou Wei Wang Lijun Zhang Xiao-bin Zhang Prognostic Value of Adrenomedullin and Natriuretic Peptides in Uroseptic Patients Induced by Ureteroscopy Mediators of Inflammation |
| title | Prognostic Value of Adrenomedullin and Natriuretic Peptides in Uroseptic Patients Induced by Ureteroscopy |
| title_full | Prognostic Value of Adrenomedullin and Natriuretic Peptides in Uroseptic Patients Induced by Ureteroscopy |
| title_fullStr | Prognostic Value of Adrenomedullin and Natriuretic Peptides in Uroseptic Patients Induced by Ureteroscopy |
| title_full_unstemmed | Prognostic Value of Adrenomedullin and Natriuretic Peptides in Uroseptic Patients Induced by Ureteroscopy |
| title_short | Prognostic Value of Adrenomedullin and Natriuretic Peptides in Uroseptic Patients Induced by Ureteroscopy |
| title_sort | prognostic value of adrenomedullin and natriuretic peptides in uroseptic patients induced by ureteroscopy |
| url | http://dx.doi.org/10.1155/2016/9743198 |
| work_keys_str_mv | AT weihu prognosticvalueofadrenomedullinandnatriureticpeptidesinurosepticpatientsinducedbyureteroscopy AT panghuzhou prognosticvalueofadrenomedullinandnatriureticpeptidesinurosepticpatientsinducedbyureteroscopy AT weiwang prognosticvalueofadrenomedullinandnatriureticpeptidesinurosepticpatientsinducedbyureteroscopy AT lijunzhang prognosticvalueofadrenomedullinandnatriureticpeptidesinurosepticpatientsinducedbyureteroscopy AT xiaobinzhang prognosticvalueofadrenomedullinandnatriureticpeptidesinurosepticpatientsinducedbyureteroscopy |