Analytical methods for nebivolol quantification in pharmaceutical formulations and biological matrices: a comprehensive review
Abstract Nebivolol, a beta-blocker commonly prescribed for the treatment of hypertension and heart failure, functions by decelerating heart rate and promoting vasodilation, thereby enhancing blood flow and reducing blood pressure. Distinctively, nebivolol elevates nitric oxide levels, facilitating s...
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| Format: | Article |
| Language: | English |
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Springer
2025-06-01
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| Series: | Discover Chemistry |
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| Online Access: | https://doi.org/10.1007/s44371-025-00213-z |
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| author | Kurdo A. Abdullah Aryan Fathulla Qader Rebaz Anwar Omer Rebaz Obaid Kareem Musher Ismael Salih |
| author_facet | Kurdo A. Abdullah Aryan Fathulla Qader Rebaz Anwar Omer Rebaz Obaid Kareem Musher Ismael Salih |
| author_sort | Kurdo A. Abdullah |
| collection | DOAJ |
| description | Abstract Nebivolol, a beta-blocker commonly prescribed for the treatment of hypertension and heart failure, functions by decelerating heart rate and promoting vasodilation, thereby enhancing blood flow and reducing blood pressure. Distinctively, nebivolol elevates nitric oxide levels, facilitating superior vasorelaxation compared to other beta-blockers. This dual mechanism renders it a potent option for hypertension management. Nebivolol is well-tolerated, particularly among patients with respiratory conditions, due to its minimal pulmonary impact. Administered once daily, it can be used as monotherapy or in combination with other antihypertensive agents to maintain optimal blood pressure control. This review comprehensively examines various analytical methodologies for the quantification of nebivolol and its combinations in pharmaceutical formulations and biological matrices. It encompasses both fundamental and advanced techniques for the estimation of nebivolol hydrochloride. Electrochemical techniques, high-performance liquid chromatography (HPLC), liquid chromatography-tandem mass spectrometry (LC–MS/MS), UV–visible spectrophotometry, and spectrofluorometric method are some of the most common ways to do an assay. Among these, HPLC coupled with spectrophotometric detection emerges as the most extensively utilized method for nebivolol assay. Graphical Abstract |
| format | Article |
| id | doaj-art-912cf5fb73ee40e2a3dd4cf7ebe515ee |
| institution | OA Journals |
| issn | 3005-1193 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Chemistry |
| spelling | doaj-art-912cf5fb73ee40e2a3dd4cf7ebe515ee2025-08-20T02:31:09ZengSpringerDiscover Chemistry3005-11932025-06-012111610.1007/s44371-025-00213-zAnalytical methods for nebivolol quantification in pharmaceutical formulations and biological matrices: a comprehensive reviewKurdo A. Abdullah0Aryan Fathulla Qader1Rebaz Anwar Omer2Rebaz Obaid Kareem3Musher Ismael Salih4Department of Chemistry, Faculty of Science and Health, Koya UniversityDepartment of Chemistry, Faculty of Science and Health, Koya UniversityDepartment of Chemistry, Faculty of Science and Health, Koya UniversityPhysics Department, College of Science, University of HalabjaDepartment of Chemistry, Faculty of Science and Health, Koya UniversityAbstract Nebivolol, a beta-blocker commonly prescribed for the treatment of hypertension and heart failure, functions by decelerating heart rate and promoting vasodilation, thereby enhancing blood flow and reducing blood pressure. Distinctively, nebivolol elevates nitric oxide levels, facilitating superior vasorelaxation compared to other beta-blockers. This dual mechanism renders it a potent option for hypertension management. Nebivolol is well-tolerated, particularly among patients with respiratory conditions, due to its minimal pulmonary impact. Administered once daily, it can be used as monotherapy or in combination with other antihypertensive agents to maintain optimal blood pressure control. This review comprehensively examines various analytical methodologies for the quantification of nebivolol and its combinations in pharmaceutical formulations and biological matrices. It encompasses both fundamental and advanced techniques for the estimation of nebivolol hydrochloride. Electrochemical techniques, high-performance liquid chromatography (HPLC), liquid chromatography-tandem mass spectrometry (LC–MS/MS), UV–visible spectrophotometry, and spectrofluorometric method are some of the most common ways to do an assay. Among these, HPLC coupled with spectrophotometric detection emerges as the most extensively utilized method for nebivolol assay. Graphical Abstracthttps://doi.org/10.1007/s44371-025-00213-zNebivololPharmaceutical analysisBeta-blockersPharmacologyHypertension |
| spellingShingle | Kurdo A. Abdullah Aryan Fathulla Qader Rebaz Anwar Omer Rebaz Obaid Kareem Musher Ismael Salih Analytical methods for nebivolol quantification in pharmaceutical formulations and biological matrices: a comprehensive review Discover Chemistry Nebivolol Pharmaceutical analysis Beta-blockers Pharmacology Hypertension |
| title | Analytical methods for nebivolol quantification in pharmaceutical formulations and biological matrices: a comprehensive review |
| title_full | Analytical methods for nebivolol quantification in pharmaceutical formulations and biological matrices: a comprehensive review |
| title_fullStr | Analytical methods for nebivolol quantification in pharmaceutical formulations and biological matrices: a comprehensive review |
| title_full_unstemmed | Analytical methods for nebivolol quantification in pharmaceutical formulations and biological matrices: a comprehensive review |
| title_short | Analytical methods for nebivolol quantification in pharmaceutical formulations and biological matrices: a comprehensive review |
| title_sort | analytical methods for nebivolol quantification in pharmaceutical formulations and biological matrices a comprehensive review |
| topic | Nebivolol Pharmaceutical analysis Beta-blockers Pharmacology Hypertension |
| url | https://doi.org/10.1007/s44371-025-00213-z |
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