Celastrol boosts fluconazole efficacy against vaginal candidiasis: in vitro and in vivo evidence

Celastrol boosts fluconazole efficacy against vaginal candidiasis: in vitro and in vivo evidence

Abstract Candida albicans is a commensal fungus that naturally inhabits the vagina. However, overgrowth of C. albicans can result in vulvovaginal candidiasis (VVC), one of the most prevalent fungal infections affecting women. The rapid emergence of azole resistance in C. albicans, in addition to the...

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Main Authors: Fatma Al-zahraa A. Yehia, Hisham A Abbas, Tarek M. Ibrahim, Basem Mansour, Zuhier A. Awan, Mohammed W. Al-Rabia, Wesam H. Abdulaal, Mustafa Adnan Zeyadi, Solomon Z. Okbazghi, Tarek S. Ibrahim, Wael A. H. Hegazy, Salwa E. Gomaa
Format: Article
Language:English
Published: SpringerOpen 2025-01-01
Series:AMB Express
Subjects:
Candida albicans
Celastrol
Efflux pumps
Vaginal candidiasis
Azole-resistance
Online Access:https://doi.org/10.1186/s13568-025-01824-6
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